Hydrogels have been prepared using two partially deacetylated hyaluronan (deHA) samples having a molar ratio of free amino groups to total initial N-acetamido groups equal to 23 and 33%, respectively. Taking advantage of such primary amino functionalities, polymeric networks could be easily obtained in aqueous media by means of two different crosslinking procedures, namely: a) Ugi multicomponent reactions and, more simply, b) glutaraldehyde reticulation. In this paper, we wish to report on the synthesis of deHA based hydrogels and, in particular, on their structural elucidation as obtained by NMR studies.
NMR STRUCTURAL STUDY OF HYDROGELS BASED ON PARTIALLY DEACETYLATED HYALURONAN / Crescenzi, Vittorio; A., Francescangeli; A. L., Segre; D., Capitani; Mannina, Luisa; D., Renier; D., Bellini. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5187. - ELETTRONICO. - 2:(2002), pp. 272-279. [10.1002/1616-5195(200208)2:6<272::AID-MABI272>3.0.CO;2-V]
NMR STRUCTURAL STUDY OF HYDROGELS BASED ON PARTIALLY DEACETYLATED HYALURONAN
CRESCENZI, Vittorio;MANNINA, LUISA;
2002
Abstract
Hydrogels have been prepared using two partially deacetylated hyaluronan (deHA) samples having a molar ratio of free amino groups to total initial N-acetamido groups equal to 23 and 33%, respectively. Taking advantage of such primary amino functionalities, polymeric networks could be easily obtained in aqueous media by means of two different crosslinking procedures, namely: a) Ugi multicomponent reactions and, more simply, b) glutaraldehyde reticulation. In this paper, we wish to report on the synthesis of deHA based hydrogels and, in particular, on their structural elucidation as obtained by NMR studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
