Profilassi antibiotica nella chirurgia maggiore O.R.L.: dati preliminari.

Head and neck malignant neoplasms often require an highly destructioe surgical treatment in body areas intensel! colonized by aerobic and anaerobic bacterìa. Infectious coruplications are usually represented by wound infections and bron' c h opu lm onarlt infe c tions. The Authors rEort prelitninary data about a randomized perspectiue study comparing !wo prophjlaxis regimens. Tueilty patients surgically treated for laryngeal, orcpharyngeal and oral neoPlasms entered in this study. Nine subjec\ receìr.ted an already wid.ely tested protocol (clindamycin + anikacin) and eleuen receiued cefotetan. Both prophylactic regimens were associated with a lou rate of infectious complication. No significant toxicity was obserued with either regimens.