Morphological, immunologic, and functional properties of peripheral blood cells from 2 patients with chronic proliferations of granular lymphocytes are described. Cells from both patients showed a heterogeneous pattern from both a morphological and immunologic standpoint, indicating a polyclonal, rather than a monoclonal, expansion of these cells. In fact, both large and small-to-medium-sized granular lymphocytes were observed, and different percentages of positivity were found in the analysis with a large panel of monoclonal antibodies. Serologic and histologic features support the hypothesis that this lymphocytosis could be secondary to bacterial or viral infections rather than a primary event, suggesting that these patients may have chronic reactive immunoregulatory disorders.

Abnormal expansions of polyclonal large to small size granular lymphocytes: Reactive or neoplastic process? / G., Semenzato; G., Pizzolo; A., Ranucci; C., Agostini; M., Chilosi; Quinti, Isabella; G., De Sanctis; B., Vercelli; F., Pandolfi. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 63:6(1984), pp. 1271-1277.

Abnormal expansions of polyclonal large to small size granular lymphocytes: Reactive or neoplastic process?

QUINTI, Isabella;
1984

Abstract

Morphological, immunologic, and functional properties of peripheral blood cells from 2 patients with chronic proliferations of granular lymphocytes are described. Cells from both patients showed a heterogeneous pattern from both a morphological and immunologic standpoint, indicating a polyclonal, rather than a monoclonal, expansion of these cells. In fact, both large and small-to-medium-sized granular lymphocytes were observed, and different percentages of positivity were found in the analysis with a large panel of monoclonal antibodies. Serologic and histologic features support the hypothesis that this lymphocytosis could be secondary to bacterial or viral infections rather than a primary event, suggesting that these patients may have chronic reactive immunoregulatory disorders.
1984
01 Pubblicazione su rivista::01a Articolo in rivista
Abnormal expansions of polyclonal large to small size granular lymphocytes: Reactive or neoplastic process? / G., Semenzato; G., Pizzolo; A., Ranucci; C., Agostini; M., Chilosi; Quinti, Isabella; G., De Sanctis; B., Vercelli; F., Pandolfi. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 63:6(1984), pp. 1271-1277.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/418643
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