Background Cancer anorexia is influenced by the neuropeptidergic and monoaminergic systems. We hypothesize that serotonin (5-HT), dopamine (DA) and neuropeptide Y (NPY) concentrations in paraventricular (PVN), ventromedial (VMN), and lateral hypothalamus (LHA) areas are abnormal in tumor-bearing rats. Methods Fifty-five Fischer rats (240-280 g) were divided into MCA tumor-bearing (TB), nontumor-bearing (NTB), pair-fed (PF), TB sacrificed at the end of experiment (TB-Terminal), TB resection (TB-Resection), NTB sham-operated (NTB-Sham) and pair-fed sham-operated (PF-Sham) groups. Rats were sacrificed at onset of anorexia (TB, NTB, and PF) and 9 days after tumor resection (TB-Resection, NTB-Sham, PF-Sham, and TB-Terminal). Bilateral PVN, VMN, and LHA were harvested for NPY, 5-HT, and DA analyses. Results Food intake decreased in TB versus NTB (P < .05). In TB versus NTB, an increase of 5-HT in PVN and VMN occurred with a concomitant decrease in DA. NPY in PVN, VMN, and LHA decreased (P < .05). In TB-Resection versus NTB-Sham, 5-HT, DA, NPY, and FI normalized after tumor resection. Conclusions Cancer anorexia is associated with abnormal serotonin, dopamine, and NPY concentrations, expressed by an increase in 5-HT and a decrease in DA and NPY. After tumor resection, these alterations normalized, providing evidence that the levels of these substances change with anorexia in tumor-bearing rats.

Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: Pre- and post-tumor resection and at death / Eduardo J. B., Ramos; Susumu, Suzuki; Michael M., Meguid; Laviano, Alessandro; Tomoi, Sato; Chung, Chen; Undurti, Das. - In: SURGERY. - ISSN 0039-6060. - 136:2(2004), pp. 270-276. [10.1016/j.surg.2004.03.016]

Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: Pre- and post-tumor resection and at death

LAVIANO, Alessandro;
2004

Abstract

Background Cancer anorexia is influenced by the neuropeptidergic and monoaminergic systems. We hypothesize that serotonin (5-HT), dopamine (DA) and neuropeptide Y (NPY) concentrations in paraventricular (PVN), ventromedial (VMN), and lateral hypothalamus (LHA) areas are abnormal in tumor-bearing rats. Methods Fifty-five Fischer rats (240-280 g) were divided into MCA tumor-bearing (TB), nontumor-bearing (NTB), pair-fed (PF), TB sacrificed at the end of experiment (TB-Terminal), TB resection (TB-Resection), NTB sham-operated (NTB-Sham) and pair-fed sham-operated (PF-Sham) groups. Rats were sacrificed at onset of anorexia (TB, NTB, and PF) and 9 days after tumor resection (TB-Resection, NTB-Sham, PF-Sham, and TB-Terminal). Bilateral PVN, VMN, and LHA were harvested for NPY, 5-HT, and DA analyses. Results Food intake decreased in TB versus NTB (P < .05). In TB versus NTB, an increase of 5-HT in PVN and VMN occurred with a concomitant decrease in DA. NPY in PVN, VMN, and LHA decreased (P < .05). In TB-Resection versus NTB-Sham, 5-HT, DA, NPY, and FI normalized after tumor resection. Conclusions Cancer anorexia is associated with abnormal serotonin, dopamine, and NPY concentrations, expressed by an increase in 5-HT and a decrease in DA and NPY. After tumor resection, these alterations normalized, providing evidence that the levels of these substances change with anorexia in tumor-bearing rats.
2004
01 Pubblicazione su rivista::01a Articolo in rivista
Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: Pre- and post-tumor resection and at death / Eduardo J. B., Ramos; Susumu, Suzuki; Michael M., Meguid; Laviano, Alessandro; Tomoi, Sato; Chung, Chen; Undurti, Das. - In: SURGERY. - ISSN 0039-6060. - 136:2(2004), pp. 270-276. [10.1016/j.surg.2004.03.016]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/41352
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