Several cases of hepatotoxicity after consumption of herbal preparations containing Chelidonium majus L. have been reported (Mazzanti G, et al.. J Ethnopharmacol 2009;124:328-32) Present work was aimed to assess if the co-treatment of C. majus and sub-toxic doses of acetaminophen can induce liver damage. The experiments were carried out in vitro in Buffalo normal Rat Liver cell line (BRL-3A) by the MTT reduction method, after 24 h of exposure and in vivo in male Wistar rats. The co-administration of C. majus and acetaminophen does not have any synergistic effect in our experimental model, suggesting that the suspected hepatotoxicity in humans is not caused by association of C. majus with potential hepatotoxic drugs.
In vitro and in vivo studies on the hepatic effect of acute administration of Chelidonium majus alone and in association with acetaminophen / Mammola, CATERINA LOREDANA; Vitalone, Annabella; DI SOTTO, Antonella; Mariani, Paola; P., Izzo; Mazzanti, Gabriela. - In: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY. - ISSN 1122-6714. - STAMPA. - 1/2 (Supplement):(2010), pp. 97-97. (Intervento presentato al convegno 64° Congresso della Società Italiana di Anatomia e Istologia tenutosi a Taormina-Messina nel 15-18 settembre).
In vitro and in vivo studies on the hepatic effect of acute administration of Chelidonium majus alone and in association with acetaminophen
MAMMOLA, CATERINA LOREDANA;VITALONE, Annabella;DI SOTTO, ANTONELLA;MARIANI, Paola;MAZZANTI, Gabriela
2010
Abstract
Several cases of hepatotoxicity after consumption of herbal preparations containing Chelidonium majus L. have been reported (Mazzanti G, et al.. J Ethnopharmacol 2009;124:328-32) Present work was aimed to assess if the co-treatment of C. majus and sub-toxic doses of acetaminophen can induce liver damage. The experiments were carried out in vitro in Buffalo normal Rat Liver cell line (BRL-3A) by the MTT reduction method, after 24 h of exposure and in vivo in male Wistar rats. The co-administration of C. majus and acetaminophen does not have any synergistic effect in our experimental model, suggesting that the suspected hepatotoxicity in humans is not caused by association of C. majus with potential hepatotoxic drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
