Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors. (C) 1997 Elsevier Science Inc.
Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats / Alessia, Pascale; Fiorenzo, Battaini; Stefano, Govoni; Michele, Persichella; Maria A., De Salvia; Cuomo, Vincenzo. - In: ALCOHOL. - ISSN 0741-8329. - STAMPA. - 14:6(1997), pp. 557-561. [10.1016/s0741-8329(97)00047-5]
Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats
CUOMO, VINCENZO
1997
Abstract
Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors. (C) 1997 Elsevier Science Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.