Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors. (C) 1997 Elsevier Science Inc.

Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats / Alessia, Pascale; Fiorenzo, Battaini; Stefano, Govoni; Michele, Persichella; Maria A., De Salvia; Cuomo, Vincenzo. - In: ALCOHOL. - ISSN 0741-8329. - STAMPA. - 14:6(1997), pp. 557-561. [10.1016/s0741-8329(97)00047-5]

Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats

CUOMO, VINCENZO
1997

Abstract

Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors. (C) 1997 Elsevier Science Inc.
1997
calcium dependent; calcium independent; cortex; cortex hippocampus; hippocampus; moderate ethanol; protein kinase c; rat; vocalization
01 Pubblicazione su rivista::01a Articolo in rivista
Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats / Alessia, Pascale; Fiorenzo, Battaini; Stefano, Govoni; Michele, Persichella; Maria A., De Salvia; Cuomo, Vincenzo. - In: ALCOHOL. - ISSN 0741-8329. - STAMPA. - 14:6(1997), pp. 557-561. [10.1016/s0741-8329(97)00047-5]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/40726
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 12
social impact