C57 BL/6J (C57) mice display a particular pattern of responses following morphine administration, such as a rapid development of tolerance to the pharmacological action of the opiate and an increase in locomotor activity after a single injection of the drug. We have measured met-enkephalin content and the responsiveness of different opiate receptors after repeated administration of morphine and naloxone. Prolonged morphine administration changes neither met-enkephalin levels, nor the density of the opiate receptors in mice brain. In contrast repeated administration of the opiate antagonist naloxone, produced a marked increase in the number of 3H- DHM and 3H- DADLE binding sites in striatum and brainstem without modifying met-enkephalin concentrations. Behavioral studies have indicated that the morphine-induced increase in locomotor activity is enhanced in naloxone pretreated mice, thus suggesting a possible correlation between the behavioral response to morphine in C57 mice and the higher number of opiate receptors in the striatum

Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioural correlates / Brunello, N; Volterra, A; DI GIULIO, Am; Cuomo, Vincenzo; Racagni, G.. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 34:(1984), pp. 1669-1678.

Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioural correlates

CUOMO, VINCENZO;
1984

Abstract

C57 BL/6J (C57) mice display a particular pattern of responses following morphine administration, such as a rapid development of tolerance to the pharmacological action of the opiate and an increase in locomotor activity after a single injection of the drug. We have measured met-enkephalin content and the responsiveness of different opiate receptors after repeated administration of morphine and naloxone. Prolonged morphine administration changes neither met-enkephalin levels, nor the density of the opiate receptors in mice brain. In contrast repeated administration of the opiate antagonist naloxone, produced a marked increase in the number of 3H- DHM and 3H- DADLE binding sites in striatum and brainstem without modifying met-enkephalin concentrations. Behavioral studies have indicated that the morphine-induced increase in locomotor activity is enhanced in naloxone pretreated mice, thus suggesting a possible correlation between the behavioral response to morphine in C57 mice and the higher number of opiate receptors in the striatum
1984
Opioid system; behavioral and biochemical studies; striatum; mice
01 Pubblicazione su rivista::01a Articolo in rivista
Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioural correlates / Brunello, N; Volterra, A; DI GIULIO, Am; Cuomo, Vincenzo; Racagni, G.. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 34:(1984), pp. 1669-1678.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/40673
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 40
  • ???jsp.display-item.citation.isi??? ND
social impact