There is increasing interest in the identification of biological markers for the early diagnosis of Parkinson's disease (PD). Previous studies indicate changes of dopamine content, tyrosine hydroxylase immunoreactivity and dopamine receptors in peripheral blood lymphocytes (PBL) in PD. Here we demonstrate a reduction of dopamine transporter immunoreactivity in PBL in the early clinical stages of the disease. These findings contribute to our understanding of the peripheral dopamine system in PD
Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease / Caronti, Brunella; Antonini, Giovanni; Calderaro, C; Palladini, G; Ruggieri, S; Pontieri, FRANCESCO ERNESTO; Colosimo, Carlo. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 108:(2001), pp. 803-807. [10.1007/s007020170030]
Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease
CARONTI, Brunella;ANTONINI, Giovanni;PONTIERI, FRANCESCO ERNESTO;COLOSIMO, Carlo
2001
Abstract
There is increasing interest in the identification of biological markers for the early diagnosis of Parkinson's disease (PD). Previous studies indicate changes of dopamine content, tyrosine hydroxylase immunoreactivity and dopamine receptors in peripheral blood lymphocytes (PBL) in PD. Here we demonstrate a reduction of dopamine transporter immunoreactivity in PBL in the early clinical stages of the disease. These findings contribute to our understanding of the peripheral dopamine system in PDI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
