Respiratory mechanical abnormalities in patients with chronic obstructive pulmonary disease (COPD) may impair cardiodynamic responses and slow down heart rate (HR) kinetics compared with normal resulting in reduced convective oxygen delivery during exercise. We reasoned that heliox breathing (79% helium-21% oxygen) and the attendant reduction of operating lung volumes should accelerate HR kinetics in the transition from rest to high-intensity exercise. Eleven male ambulatory patients with clinically stable COPD undertook constant work-rate cycle testing at 80% of each individuals' maximum work capacity while breathing room air (RA) or heliox (HX), randomly. Mean response time (MRT) for HR and dynamic end-expiratory lung volume (EELV) were measured. Resting EELV was not affected by HX breathing, while exercise EELV decreased significantly by 0.23 L at isotime during HX breathing compared with RA. During FIX breathing, MRT for HR significantly accelerated (p = 0.002) by an average of 20 s (i.e., 17%). Speeded MRT for HR correlated with indices of reduced lung hyperinflation, such as EELV at isotime (r = 0.88, p = 0.03), and with improved exercise endurance time (r = -0.64, p = 0.03). The results confirm that HX-induced reduction of dynamic lung hyperinflation is associated with consistent improvement in indices of cardio-circulatory function such as HR kinetics in the rest-to-exercise transition in COPD patients.

Effect of heliox on heart rate kinetics and dynamic hyperinflation during high-intensity exercise in COPD / Pierantonio, Laveneziana; Gabriele, Valli; Paolo, Onorati; Patrizia, Paoletti; Alessandro Maria, Ferrazza; Palange, Paolo. - In: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. - ISSN 1439-6319. - 111:2(2011), pp. 225-234. [10.1007/s00421-010-1643-z]

Effect of heliox on heart rate kinetics and dynamic hyperinflation during high-intensity exercise in COPD

PALANGE, Paolo
2011

Abstract

Respiratory mechanical abnormalities in patients with chronic obstructive pulmonary disease (COPD) may impair cardiodynamic responses and slow down heart rate (HR) kinetics compared with normal resulting in reduced convective oxygen delivery during exercise. We reasoned that heliox breathing (79% helium-21% oxygen) and the attendant reduction of operating lung volumes should accelerate HR kinetics in the transition from rest to high-intensity exercise. Eleven male ambulatory patients with clinically stable COPD undertook constant work-rate cycle testing at 80% of each individuals' maximum work capacity while breathing room air (RA) or heliox (HX), randomly. Mean response time (MRT) for HR and dynamic end-expiratory lung volume (EELV) were measured. Resting EELV was not affected by HX breathing, while exercise EELV decreased significantly by 0.23 L at isotime during HX breathing compared with RA. During FIX breathing, MRT for HR significantly accelerated (p = 0.002) by an average of 20 s (i.e., 17%). Speeded MRT for HR correlated with indices of reduced lung hyperinflation, such as EELV at isotime (r = 0.88, p = 0.03), and with improved exercise endurance time (r = -0.64, p = 0.03). The results confirm that HX-induced reduction of dynamic lung hyperinflation is associated with consistent improvement in indices of cardio-circulatory function such as HR kinetics in the rest-to-exercise transition in COPD patients.
2011
aged; chronic obstructive; chronic obstructive pulmonary disease; double-blind method; drug effects; drug effects/physiology; dynamic lung hyperinflation; dyspnoea; exercise; exercise test; exercise tolerance; heart rate; heart rate kinetics; heliox; helium; hemodynamics; humans; inhalation; inspiratory capacity; kinetics; male; middle aged; oxygen; pathology/physiopathology; pharmacology; physical exertion; physiology; placebos; pulmonary disease
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Effect of heliox on heart rate kinetics and dynamic hyperinflation during high-intensity exercise in COPD / Pierantonio, Laveneziana; Gabriele, Valli; Paolo, Onorati; Patrizia, Paoletti; Alessandro Maria, Ferrazza; Palange, Paolo. - In: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. - ISSN 1439-6319. - 111:2(2011), pp. 225-234. [10.1007/s00421-010-1643-z]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/401310
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