The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a significant decrease in the length of ultrasounds was found in the group of animals treated with these benzodiazepines. The effects of diazepam were counteracted by the benzodiazepine-antagonist Ro 15-1788. On the other hand, neither a neuroleptic agent, such as haloperidol (0.5-1 mg/kg), nor an antidepressant, such as desipramine (5-10 mg/kg) influenced the parameters of ultrasonic emission in this experimental situation. The present results suggest that ultrasonic vocalization in response to unavoidable aversive stimuli could be considered as a potential new tool for studying drugs with antianxiety properties.

Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines / Cuomo, Vincenzo; Cagiano, R; DE SALVIA, Ma; Maselli, Ma; Renna, G; Racagni, G.. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 43:(1988), pp. 485-491. [10.1016/0024-3205(88)90149-X]

Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines

CUOMO, VINCENZO;
1988

Abstract

The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a significant decrease in the length of ultrasounds was found in the group of animals treated with these benzodiazepines. The effects of diazepam were counteracted by the benzodiazepine-antagonist Ro 15-1788. On the other hand, neither a neuroleptic agent, such as haloperidol (0.5-1 mg/kg), nor an antidepressant, such as desipramine (5-10 mg/kg) influenced the parameters of ultrasonic emission in this experimental situation. The present results suggest that ultrasonic vocalization in response to unavoidable aversive stimuli could be considered as a potential new tool for studying drugs with antianxiety properties.
1988
benzodiazepine; Ro 15-1788; ultrasonic vocalization; rat
01 Pubblicazione su rivista::01a Articolo in rivista
Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines / Cuomo, Vincenzo; Cagiano, R; DE SALVIA, Ma; Maselli, Ma; Renna, G; Racagni, G.. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 43:(1988), pp. 485-491. [10.1016/0024-3205(88)90149-X]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/38997
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 89
  • ???jsp.display-item.citation.isi??? 89
social impact