The pyridoxal Schiff bases of the polypeptides poly(l-lysine), poly(l-ornithine), and poly(l-α,γ-diaminobutyric acid) were prepared and investigated in water/methanol by CD spectra and equilibrium dialysis experiments. Only the poly(l-α,γ-diaminobutyric acid) derivative is characterized by a relevant optical activity similar to that found in pyridoxal enzymes. The stereospecific interactions between the pyridoxylideneimine group and the polypeptide chain prevent the hydrolysis reaction of the aldimine bond.

Conformational studies on the pyridoxal Schiff bases of polypeptides / Dentini, Mariella; G., Perretti; Savino, Maria; DE SANTIS, Pasquale; A. S., Verdini. - In: BIOPOLYMERS. - ISSN 0006-3525. - STAMPA. - 17:4(1978), pp. 897-908. [10.1002/bip.1978.360170408]

Conformational studies on the pyridoxal Schiff bases of polypeptides

DENTINI, Mariella;SAVINO, Maria;DE SANTIS, Pasquale;
1978

Abstract

The pyridoxal Schiff bases of the polypeptides poly(l-lysine), poly(l-ornithine), and poly(l-α,γ-diaminobutyric acid) were prepared and investigated in water/methanol by CD spectra and equilibrium dialysis experiments. Only the poly(l-α,γ-diaminobutyric acid) derivative is characterized by a relevant optical activity similar to that found in pyridoxal enzymes. The stereospecific interactions between the pyridoxylideneimine group and the polypeptide chain prevent the hydrolysis reaction of the aldimine bond.
1978
chiral discrimination; circular-dichroism; pyridoxal schiff bases of the polypeptides
01 Pubblicazione su rivista::01a Articolo in rivista
Conformational studies on the pyridoxal Schiff bases of polypeptides / Dentini, Mariella; G., Perretti; Savino, Maria; DE SANTIS, Pasquale; A. S., Verdini. - In: BIOPOLYMERS. - ISSN 0006-3525. - STAMPA. - 17:4(1978), pp. 897-908. [10.1002/bip.1978.360170408]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/389175
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