The aim of the present study was to investigate the influence of prenatal exposure to carbon monoxide (CO) on Vascular reactivity of rat resistance vessels, in different stages of neurogenesis. Both prenatally CC-exposed and control male Wistar pups (5-7, 9-11, 14-16, 20-22 days) were tested vs respective 60 day adult rats. The results showed that: (i) at 5-7 days of age, TTX caused a more marked inhibition of perivascular nerve stimulation (PNS)-evoked vasoconstriction in CO-exposed animals with respect to controls; (ii) the NO-related relaxant effect by ACh in CO-exposed group appeared earlier (5-7 days) than in control group (9-11 days); (iii) the contractile response evoked by ACh on resting tone disappeared earlier (after 14-16 days) than in control group (after 20-22 days). These observations suggested that CO-exposure might induce changes in nerve electrophysiological properties and might cause a precocious maturation of the NO-related enzymatic mechanism implicated in ACh-relaxation
Prenatal exposure to carbon monoxide and vascular responsiveness of rat restistance vessels / Montagnani, M; Serio, M; Potenza, Ma; Mansi, G; DE SALVIA, Ma; Cagiano, R; Cuomo, Vincenzo; MITOLO CHIEPPA, D.. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 59(18):(1996), pp. 1553-1561. [10.1016/0024-3205(96)00486-9]
Prenatal exposure to carbon monoxide and vascular responsiveness of rat restistance vessels
CUOMO, VINCENZO;
1996
Abstract
The aim of the present study was to investigate the influence of prenatal exposure to carbon monoxide (CO) on Vascular reactivity of rat resistance vessels, in different stages of neurogenesis. Both prenatally CC-exposed and control male Wistar pups (5-7, 9-11, 14-16, 20-22 days) were tested vs respective 60 day adult rats. The results showed that: (i) at 5-7 days of age, TTX caused a more marked inhibition of perivascular nerve stimulation (PNS)-evoked vasoconstriction in CO-exposed animals with respect to controls; (ii) the NO-related relaxant effect by ACh in CO-exposed group appeared earlier (5-7 days) than in control group (9-11 days); (iii) the contractile response evoked by ACh on resting tone disappeared earlier (after 14-16 days) than in control group (after 20-22 days). These observations suggested that CO-exposure might induce changes in nerve electrophysiological properties and might cause a precocious maturation of the NO-related enzymatic mechanism implicated in ACh-relaxationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
