We report the case of a cocaine abuser who presented two consecutive episodes of acute leukoencephalopathy, documented by serial MRI, with favourable outcome. Clinical findings and brain imaging led to the diagnosis of cocaine-induced toxic leukoencephalopathy and other possible mimickers have been excluded on the basis of clinical assessment. The patient's unexpected recovery on neurological and neuropsychological examination, despite initially severe neurological symptoms, is striking and differs from more common reports of a rapid progression to death. Of note, case presented in the peculiar form of recurrent episodes of acute leukoencephalopathy, with favourable outcome, which, to our knowledge, has not been described yet. We speculate about the aetiology of this condition, which is still poorly understood. (C) 2011 Elsevier Inc. All rights reserved.

Recurrent leukoencephalopathy in a cocaine abuser / Bianco, Federico; Iacovelli, Elisa; Tinelli, Emanuele; Lepre, Chiara; Pauri, Flavia. - In: NEUROTOXICOLOGY. - ISSN 0161-813X. - STAMPA. - 32:4(2011), pp. 410-412. [10.1016/j.neuro.2011.03.005]

Recurrent leukoencephalopathy in a cocaine abuser

BIANCO, Federico;IACOVELLI, ELISA;TINELLI, EMANUELE;LEPRE, CHIARA;PAURI, FLAVIA
2011

Abstract

We report the case of a cocaine abuser who presented two consecutive episodes of acute leukoencephalopathy, documented by serial MRI, with favourable outcome. Clinical findings and brain imaging led to the diagnosis of cocaine-induced toxic leukoencephalopathy and other possible mimickers have been excluded on the basis of clinical assessment. The patient's unexpected recovery on neurological and neuropsychological examination, despite initially severe neurological symptoms, is striking and differs from more common reports of a rapid progression to death. Of note, case presented in the peculiar form of recurrent episodes of acute leukoencephalopathy, with favourable outcome, which, to our knowledge, has not been described yet. We speculate about the aetiology of this condition, which is still poorly understood. (C) 2011 Elsevier Inc. All rights reserved.
2011
cocaine; leukoencephalopathy; mri; magnetic resonance imaging; posterior reversible encephalopathy syndrome; pres; toxic leukoencephalopathy
01 Pubblicazione su rivista::01a Articolo in rivista
Recurrent leukoencephalopathy in a cocaine abuser / Bianco, Federico; Iacovelli, Elisa; Tinelli, Emanuele; Lepre, Chiara; Pauri, Flavia. - In: NEUROTOXICOLOGY. - ISSN 0161-813X. - STAMPA. - 32:4(2011), pp. 410-412. [10.1016/j.neuro.2011.03.005]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/384860
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