N-Acetylcysteine is useful in the short-term treatment of severe Raynaud's phenomenon and digital ulcers (DU) in patients with systemic sclerosis (SSc), but its long-term effects are largely unknown. The aim of this study was to report long-term outcome (median follow-up 3 years) in a prospective study of a cohort of 50 consecutive patients with SSc who received N-acetylcysteine (NAC) infusional therapy every 2 weeks. We observed a reduction of DU/patient/year (4.5 ± 3.1 vs 0.81 ± 0.79) and DU ulcer visual analog scale (VAS; 6.88 ± 2.62 vs 3.20 ± 1.80), a decrease of the Raynaud’s phenomenon (RP) number attacks (7.18 ± 3.87 vs 3 ± 1.92), and RP VAS (6.24 ± 1.92 vs 3.62 ± 1.48). In this study, we did not observe serious adverse events in patients. Minor side effects were flushing (two patients) and headache (one patient). NAC infusion was generally well tolerated, and nobody had to discontinue the treatment. In conclusion, long-term therapy with NAC, in patients with SSc, has a durable effectiveness on ischemic ulcers and Raynaud's phenomenon.

The treatment with N-acetylcysteine of Raynaud's phenomenon and ischemic ulcers therapy in sclerodermic patients: a prospective observational study of 50 patients / Rosato, Edoardo; Borghese, F; Pisarri, Simonetta; Salsano, Felice. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 28:12(2009), pp. 1379-1384. [10.1007/s10067-009-1251-7]

The treatment with N-acetylcysteine of Raynaud's phenomenon and ischemic ulcers therapy in sclerodermic patients: a prospective observational study of 50 patients.

ROSATO, Edoardo;PISARRI, Simonetta;SALSANO, Felice
2009

Abstract

N-Acetylcysteine is useful in the short-term treatment of severe Raynaud's phenomenon and digital ulcers (DU) in patients with systemic sclerosis (SSc), but its long-term effects are largely unknown. The aim of this study was to report long-term outcome (median follow-up 3 years) in a prospective study of a cohort of 50 consecutive patients with SSc who received N-acetylcysteine (NAC) infusional therapy every 2 weeks. We observed a reduction of DU/patient/year (4.5 ± 3.1 vs 0.81 ± 0.79) and DU ulcer visual analog scale (VAS; 6.88 ± 2.62 vs 3.20 ± 1.80), a decrease of the Raynaud’s phenomenon (RP) number attacks (7.18 ± 3.87 vs 3 ± 1.92), and RP VAS (6.24 ± 1.92 vs 3.62 ± 1.48). In this study, we did not observe serious adverse events in patients. Minor side effects were flushing (two patients) and headache (one patient). NAC infusion was generally well tolerated, and nobody had to discontinue the treatment. In conclusion, long-term therapy with NAC, in patients with SSc, has a durable effectiveness on ischemic ulcers and Raynaud's phenomenon.
2009
digital ulcer; N-ACETYLCYSTEINE; RAYNAUD'S PHENOMENON; SYSTEMIC SCLEROSIS
01 Pubblicazione su rivista::01a Articolo in rivista
The treatment with N-acetylcysteine of Raynaud's phenomenon and ischemic ulcers therapy in sclerodermic patients: a prospective observational study of 50 patients / Rosato, Edoardo; Borghese, F; Pisarri, Simonetta; Salsano, Felice. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 28:12(2009), pp. 1379-1384. [10.1007/s10067-009-1251-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/381983
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