Monoclonal antibodies, first introduced in cancer therapy and to prevent allograft rejection, represent new pharmacological tools for the treatment of autoimmune diseases. With the knowledge of immunological movements in autoimmunity, it is now possible to target each single step of the immune process, from the activation of T lymphocytes in lymph nodes to the formation of the immunological synapse, and to T cell differentiation and cytokine production. However, this approach is still not devoid of adverse effects. In fact, even if monoclonal antibodies exert selective immunomodulation by targeting only cells expressing a specific antigen, a widespread perturbation of the immune system is induced, leading to a predisposition for infections and infestations and to the occurrence of tumours.

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases / Bruno, Valeria Maria Gloria; Battaglia, Giuseppe; Nicoletti, Ferdinando. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 31:3(2011), pp. S283-S288. [10.1007/s10072-010-0382-6]

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases

BRUNO, Valeria Maria Gloria;BATTAGLIA, Giuseppe;NICOLETTI, Ferdinando
2011

Abstract

Monoclonal antibodies, first introduced in cancer therapy and to prevent allograft rejection, represent new pharmacological tools for the treatment of autoimmune diseases. With the knowledge of immunological movements in autoimmunity, it is now possible to target each single step of the immune process, from the activation of T lymphocytes in lymph nodes to the formation of the immunological synapse, and to T cell differentiation and cytokine production. However, this approach is still not devoid of adverse effects. In fact, even if monoclonal antibodies exert selective immunomodulation by targeting only cells expressing a specific antigen, a widespread perturbation of the immune system is induced, leading to a predisposition for infections and infestations and to the occurrence of tumours.
2011
biological drugs; biological drugs monoclonal antibodies autoimmune diseases multiple sclerosis; autoimmune diseases; multiple sclerosis; monoclonal antibodies
01 Pubblicazione su rivista::01a Articolo in rivista
The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases / Bruno, Valeria Maria Gloria; Battaglia, Giuseppe; Nicoletti, Ferdinando. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 31:3(2011), pp. S283-S288. [10.1007/s10072-010-0382-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/376475
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