BACKGROUND: Linear immunoglobulin A bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease, rarely induced by drugs. METHODS: We describe a case of a 47-year-old man who developed a severe blistering eruption after therapy with amoxicillin-clavulanic acid. RESULTS: Histopathologic examination and direct immunofluorescence were consistent with a diagnosis of LABD. Therapy with dapsone controlled the disease but, after sun exposure, there was a worsening of the illness. CONCLUSION: To our knowledge, this is the first case of amoxicillin-clavulanic acid-induced LABD in an adult.
Amoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literature / Panasiti, Vincenzo; Rossi, Mariarita; Devirgiliis, Valeria; Curzio, Michela; Bottoni, Ugo; Calvieri, Stefano. - In: INTERNATIONAL JOURNAL OF DERMATOLOGY. - ISSN 0011-9059. - 48:9(2009), pp. 1006-1010. [10.1111/j.1365-4632.2009.04104.x]
Amoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literature
PANASITI, VINCENZO;ROSSI, MARIARITA;DEVIRGILIIS, VALERIA;CURZIO, MICHELA;BOTTONI, Ugo;CALVIERI, Stefano
2009
Abstract
BACKGROUND: Linear immunoglobulin A bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease, rarely induced by drugs. METHODS: We describe a case of a 47-year-old man who developed a severe blistering eruption after therapy with amoxicillin-clavulanic acid. RESULTS: Histopathologic examination and direct immunofluorescence were consistent with a diagnosis of LABD. Therapy with dapsone controlled the disease but, after sun exposure, there was a worsening of the illness. CONCLUSION: To our knowledge, this is the first case of amoxicillin-clavulanic acid-induced LABD in an adult.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
