A simple preparation of a new hydrosoluble paclitaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described. Bioconjugate 8 was obtained by coupling hyaluronic acid (2) to paclitaxel (1) by means of a 4-hydroxybutanoic acid derived linker (Scheme 2).

A new and simply available class of hydrosoluble bioconjugates by coupling paclitaxel to hyaluronic acid through a 4-hydroxybutanoic acid derived linker / Leonelli, Francesca; LA BELLA, Angela; Andrea, Francescangeli; Roberta, Joudioux; Agostina Lina, Capodilupo; Marina, Quagliariello; Migneco, Luisa Maria; MARINI BETTOLO, Rinaldo; Vittorio, Crescenzi; G., De Luca; Davide, Renier. - In: HELVETICA CHIMICA ACTA. - ISSN 0018-019X. - STAMPA. - 88:1(2005), pp. 154-159. [10.1002/hlca.200490289]

A new and simply available class of hydrosoluble bioconjugates by coupling paclitaxel to hyaluronic acid through a 4-hydroxybutanoic acid derived linker

LEONELLI, Francesca;LA BELLA, ANGELA;MIGNECO, Luisa Maria;MARINI BETTOLO, Rinaldo;
2005

Abstract

A simple preparation of a new hydrosoluble paclitaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described. Bioconjugate 8 was obtained by coupling hyaluronic acid (2) to paclitaxel (1) by means of a 4-hydroxybutanoic acid derived linker (Scheme 2).
2005
01 Pubblicazione su rivista::01a Articolo in rivista
A new and simply available class of hydrosoluble bioconjugates by coupling paclitaxel to hyaluronic acid through a 4-hydroxybutanoic acid derived linker / Leonelli, Francesca; LA BELLA, Angela; Andrea, Francescangeli; Roberta, Joudioux; Agostina Lina, Capodilupo; Marina, Quagliariello; Migneco, Luisa Maria; MARINI BETTOLO, Rinaldo; Vittorio, Crescenzi; G., De Luca; Davide, Renier. - In: HELVETICA CHIMICA ACTA. - ISSN 0018-019X. - STAMPA. - 88:1(2005), pp. 154-159. [10.1002/hlca.200490289]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/365127
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