Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.
A Case of Coloboma in a Newborn to a Woman Taking Mycophenolate Mofetil in Pregnancy After Kidney Transplantation / FRAMARINO DEI MALATESTA, Marialuisa; B., Rocca; T., Gentile; T., Hadjistilianou; M., Borri; S., De Francesco; F., Pisani; A., Famulari. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 41:4(2009), pp. 1407-1409. (Intervento presentato al convegno 32nd Congress of the Italian-Transplantation-Society tenutosi a Sorrento, ITALY nel DEC 14-16, 2008) [10.1016/j.transproceed.2009.03.088].
A Case of Coloboma in a Newborn to a Woman Taking Mycophenolate Mofetil in Pregnancy After Kidney Transplantation
FRAMARINO DEI MALATESTA, Marialuisa;
2009
Abstract
Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
