Amino esters were used as nucleophiles in the reaction with Meldrum's acid to obtain monosubstituted malonic acids that reacted under coupling reaction conditions with a second different amino ester residue to give single > COCH2CO < retropeptide units in high overall yields. The synthetic procedure led to the construction of a 4 x 5 combinatorial library of malonyl peptides.
Solution-phase parallel synthesis of dissymmetric disubstituted malonamides carrying amino ester residues / Fioravanti, Stefania; Morreale, Alberto; Pellacani, Lucio; Ramadori, Federico; Tardella, Paolo Antonio. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 2007:17(2007), pp. 2759-2761. [10.1055/s-2007-986659]
Solution-phase parallel synthesis of dissymmetric disubstituted malonamides carrying amino ester residues
FIORAVANTI, Stefania;MORREALE, Alberto;PELLACANI, Lucio;RAMADORI, FEDERICO;TARDELLA, Paolo Antonio
2007
Abstract
Amino esters were used as nucleophiles in the reaction with Meldrum's acid to obtain monosubstituted malonic acids that reacted under coupling reaction conditions with a second different amino ester residue to give single > COCH2CO < retropeptide units in high overall yields. The synthetic procedure led to the construction of a 4 x 5 combinatorial library of malonyl peptides.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
