The aim of this study was to assess whether adherence to a restricted-calorie, Mediterranean-type diet improves endothelial dysfunction and markers of oxidative stress in patients with metabolic syndrome. A moderately low-calorie (600 calories/day negative energy balance), low-fat, high-carbohydrate diet (<30% energy from fat, <10% from saturated fat and 55% from carbohydrate) was prescribed to 53 outpatients with the metabolic syndrome. Participants were divided into two groups according to body weight loss > or < 5% after 6 months. Group A (n = 23) showed a remarkable decrease in body weight (-6. 8%), body-mass-index (-4. 6%), waist circumference (-4. 8%), HOMA-IR (-27. 2%), plasma glucose, glycosylated haemoglobin, total and LDL-cholesterol, blood pressure, serum NOX2 (the catalytic core of NADPH oxidase) (-22. 2%) and urinary8-isoprostanes (-39. 0%) and an increase of serum NOx (Nitrite/Nitrate) (+116. 8%) and adiponectine (+125. 5%) as compared with those in group B (n = 30). A statistically significant increase in brachial artery flow-mediated dilatation was observed in group A (+24. 7%; p < 0. 001), while no changes were present in group B. Variations of flow-mediated dilatation were statistically and negatively correlated with changes of serum NOX2 levels (p = 0. 04), body-mass-index (p < 0. 01), waist circumference (0. 01), glycosylated haemoglobin (p < 0. 01), LDL-cholesterol (p < 0. 01) and triglycerides (p < 0. 05) and positively correlated with changes of serum NOx (p < 0. 001) and adiponectin (p = 0. 01). The results show that moderate weight loss is able to improve endothelial dysfunction in patients with the metabolic syndrome. The coexistent decrease of NOX2 activation suggests a role for oxidative stress in eliciting artery dysfunction. © 2011 SIMI.

Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome / Angelico, Francesco; Loffredo, Lorenzo; Pignatelli, Pasquale; Augelletti, Teresa; Carnevale, Roberto; Antonio, Pacella; Fabiana, Albanese; Ilaria, Mancini; Serena Di, Santo; DEL BEN, Maria; Violi, Francesco. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - ELETTRONICO. - 7:3(2012), pp. 219-227. [10.1007/s11739-011-0591-x]

Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome

ANGELICO, Francesco;LOFFREDO, Lorenzo;PIGNATELLI, Pasquale;AUGELLETTI, TERESA;CARNEVALE, Roberto;Fabiana Albanese;DEL BEN, Maria;VIOLI, Francesco
2012

Abstract

The aim of this study was to assess whether adherence to a restricted-calorie, Mediterranean-type diet improves endothelial dysfunction and markers of oxidative stress in patients with metabolic syndrome. A moderately low-calorie (600 calories/day negative energy balance), low-fat, high-carbohydrate diet (<30% energy from fat, <10% from saturated fat and 55% from carbohydrate) was prescribed to 53 outpatients with the metabolic syndrome. Participants were divided into two groups according to body weight loss > or < 5% after 6 months. Group A (n = 23) showed a remarkable decrease in body weight (-6. 8%), body-mass-index (-4. 6%), waist circumference (-4. 8%), HOMA-IR (-27. 2%), plasma glucose, glycosylated haemoglobin, total and LDL-cholesterol, blood pressure, serum NOX2 (the catalytic core of NADPH oxidase) (-22. 2%) and urinary8-isoprostanes (-39. 0%) and an increase of serum NOx (Nitrite/Nitrate) (+116. 8%) and adiponectine (+125. 5%) as compared with those in group B (n = 30). A statistically significant increase in brachial artery flow-mediated dilatation was observed in group A (+24. 7%; p < 0. 001), while no changes were present in group B. Variations of flow-mediated dilatation were statistically and negatively correlated with changes of serum NOX2 levels (p = 0. 04), body-mass-index (p < 0. 01), waist circumference (0. 01), glycosylated haemoglobin (p < 0. 01), LDL-cholesterol (p < 0. 01) and triglycerides (p < 0. 05) and positively correlated with changes of serum NOx (p < 0. 001) and adiponectin (p = 0. 01). The results show that moderate weight loss is able to improve endothelial dysfunction in patients with the metabolic syndrome. The coexistent decrease of NOX2 activation suggests a role for oxidative stress in eliciting artery dysfunction. © 2011 SIMI.
2012
atherosclerosis; diet; endothelial dysfunction; metabolic syndrome; oxidative stress
01 Pubblicazione su rivista::01a Articolo in rivista
Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome / Angelico, Francesco; Loffredo, Lorenzo; Pignatelli, Pasquale; Augelletti, Teresa; Carnevale, Roberto; Antonio, Pacella; Fabiana, Albanese; Ilaria, Mancini; Serena Di, Santo; DEL BEN, Maria; Violi, Francesco. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - ELETTRONICO. - 7:3(2012), pp. 219-227. [10.1007/s11739-011-0591-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/360982
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