Chlamydia pneumoniae, an obligate intracellular pathogen, is well-known as etiological agent of acute respiratory infections; the repeated or prolonged exposure to chlamydial antigens may promote the persistence of C pneumoniae in the respiratory tract leading to chronic diseases, such as chronic obstructive pulmonary disease and asthma. The predilection of C pneumoniae to cause respiratory tract infections combined with its persistent nature suggest that it might play a role in lung cancer. The aim of our study is to evaluate the involvement of C pneumoniae in pathogenesis of lung cancer. We therefore investigated the presence of C pneumoniae DNA in tumor lung tissues by using real-time PCR assay. Simultaneously, tumor and healthy tissues from the same patient with primary carcinoma lung were analyzed. C. pneumoniae DNA was not detected in a single lung tumor tissue by means of an highly sensitive, and specific real-time PCR assay based on FRET hybridization probes. In conclusion, this study does not support the involvement of C. pneumoniae in the pathogenesis of lung cancer, suggesting that further investigations are needed to clarify other potential causative factors for the development of this malignancy.

No evidence of involvement of Chlamydia pneumoniae in lung cancer by means of quantitative real-time polymerase chain reaction / Sessa, Rosa; Santino, Iolanda; DI PIETRO, Marisa; Schiavoni, Giovanna; C., Ripa; M., Galdiero; Iannone, Manuela; Izzo, Luciano; Mingazzini, Pietro; Bolognese, Antonio; DEL PIANO, Massimo. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 21:2(2008), pp. 415-420.

No evidence of involvement of Chlamydia pneumoniae in lung cancer by means of quantitative real-time polymerase chain reaction

SESSA, Rosa
;
SANTINO, Iolanda;DI PIETRO, Marisa;SCHIAVONI, Giovanna;IANNONE, MANUELA;IZZO, Luciano;MINGAZZINI, Pietro;BOLOGNESE, Antonio;DEL PIANO, Massimo
2008

Abstract

Chlamydia pneumoniae, an obligate intracellular pathogen, is well-known as etiological agent of acute respiratory infections; the repeated or prolonged exposure to chlamydial antigens may promote the persistence of C pneumoniae in the respiratory tract leading to chronic diseases, such as chronic obstructive pulmonary disease and asthma. The predilection of C pneumoniae to cause respiratory tract infections combined with its persistent nature suggest that it might play a role in lung cancer. The aim of our study is to evaluate the involvement of C pneumoniae in pathogenesis of lung cancer. We therefore investigated the presence of C pneumoniae DNA in tumor lung tissues by using real-time PCR assay. Simultaneously, tumor and healthy tissues from the same patient with primary carcinoma lung were analyzed. C. pneumoniae DNA was not detected in a single lung tumor tissue by means of an highly sensitive, and specific real-time PCR assay based on FRET hybridization probes. In conclusion, this study does not support the involvement of C. pneumoniae in the pathogenesis of lung cancer, suggesting that further investigations are needed to clarify other potential causative factors for the development of this malignancy.
2008
chlamydia pneumoniae; lung cancer; real-time pcr
01 Pubblicazione su rivista::01a Articolo in rivista
No evidence of involvement of Chlamydia pneumoniae in lung cancer by means of quantitative real-time polymerase chain reaction / Sessa, Rosa; Santino, Iolanda; DI PIETRO, Marisa; Schiavoni, Giovanna; C., Ripa; M., Galdiero; Iannone, Manuela; Izzo, Luciano; Mingazzini, Pietro; Bolognese, Antonio; DEL PIANO, Massimo. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 21:2(2008), pp. 415-420.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/360774
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