The synthesis of bicyclo[2.2.2]octane patchouli alcohol analogues by the Sakurai conjugate addition and Nagata cyclization is described. By this approach, complementary to those so far adopted and based on the Diels-Alder addition, known analogues 2, 3 and 20 and new analogues 8-11, with 1-isopropylbicyclo[2.2.2]octane structure, could be obtained. The olfactory properties of 8 and 10 were also evaluated.

Bicyclo[2.2.2]octane Analogues of Patchouli Alcohol by Sakurai Reaction and Nagata Cyclization. Synthesis and Olfactory Properties of Novel Isopropyl Derivatives / LA BELLA, Angela; Popolla, I; Felici, M; Leonelli, Francesca; Ceccacci, Francesca; Filocamo, Luigi; Migneco, Luisa Maria; MARINI BETTOLO, Rinaldo. - In: ARKIVOC. - ISSN 1551-7004. - ELETTRONICO. - iii:(2008), pp. 80-90.

Bicyclo[2.2.2]octane Analogues of Patchouli Alcohol by Sakurai Reaction and Nagata Cyclization. Synthesis and Olfactory Properties of Novel Isopropyl Derivatives

LA BELLA, ANGELA;LEONELLI, Francesca;CECCACCI, FRANCESCA;FILOCAMO, Luigi;MIGNECO, Luisa Maria;MARINI BETTOLO, Rinaldo
2008

Abstract

The synthesis of bicyclo[2.2.2]octane patchouli alcohol analogues by the Sakurai conjugate addition and Nagata cyclization is described. By this approach, complementary to those so far adopted and based on the Diels-Alder addition, known analogues 2, 3 and 20 and new analogues 8-11, with 1-isopropylbicyclo[2.2.2]octane structure, could be obtained. The olfactory properties of 8 and 10 were also evaluated.
2008
01 Pubblicazione su rivista::01a Articolo in rivista
Bicyclo[2.2.2]octane Analogues of Patchouli Alcohol by Sakurai Reaction and Nagata Cyclization. Synthesis and Olfactory Properties of Novel Isopropyl Derivatives / LA BELLA, Angela; Popolla, I; Felici, M; Leonelli, Francesca; Ceccacci, Francesca; Filocamo, Luigi; Migneco, Luisa Maria; MARINI BETTOLO, Rinaldo. - In: ARKIVOC. - ISSN 1551-7004. - ELETTRONICO. - iii:(2008), pp. 80-90.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/360319
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