Cachexia, literally “bad condition”, a syndrome reported even in the Old Testament, is associated to a variety of chronic diseases and to several kinds of traumatic injuries. Although an official definition of cachexia is still missing, this multi systemic syndrome is characterized by a massive loss of skeletal muscle and fat tissue. Such an important loss of body mass is often a direct cause of death, interferes with therapies and always represents a poor prognostic factor. In sharp contrast with the management of chronic disease states, a cure for cachexia is still missing. In recent years striking discoveries have cast light upon the molecular mechanisms underlying cachexia. Muscle specific targets for pharma-cological, gene or cell therapy approaches have been identified and are summarized in this review. Although limited to cancer cachexia, the first phase I-III clinical trials have been recently terminated or are ongoing. These efforts are opening the possibility to prevent cachexia or treat it with novel approaches in the near future.

CACHEXIA: NOVEL PERSPECTIVES FOR AN OLD SYNDROME / Coletti, Dario; Belli, L; Adamo, Sergio. - In: BASIC AND APPLIED MYOLOGY. - ISSN 1120-9992. - STAMPA. - 16:5&6(2006), pp. 131-139.

CACHEXIA: NOVEL PERSPECTIVES FOR AN OLD SYNDROME

COLETTI, Dario;ADAMO, Sergio
2006

Abstract

Cachexia, literally “bad condition”, a syndrome reported even in the Old Testament, is associated to a variety of chronic diseases and to several kinds of traumatic injuries. Although an official definition of cachexia is still missing, this multi systemic syndrome is characterized by a massive loss of skeletal muscle and fat tissue. Such an important loss of body mass is often a direct cause of death, interferes with therapies and always represents a poor prognostic factor. In sharp contrast with the management of chronic disease states, a cure for cachexia is still missing. In recent years striking discoveries have cast light upon the molecular mechanisms underlying cachexia. Muscle specific targets for pharma-cological, gene or cell therapy approaches have been identified and are summarized in this review. Although limited to cancer cachexia, the first phase I-III clinical trials have been recently terminated or are ongoing. These efforts are opening the possibility to prevent cachexia or treat it with novel approaches in the near future.
2006
novel; perspective; syndrome
01 Pubblicazione su rivista::01a Articolo in rivista
CACHEXIA: NOVEL PERSPECTIVES FOR AN OLD SYNDROME / Coletti, Dario; Belli, L; Adamo, Sergio. - In: BASIC AND APPLIED MYOLOGY. - ISSN 1120-9992. - STAMPA. - 16:5&6(2006), pp. 131-139.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/35950
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