More than two decades have passed since neoadjuvant chemotherapy has been introduced in the clinical practice. After several pilot studies, randomized trials and meta-analysis have confirmed the validity of this therapeutic strategy and in particular of neoadjuvant chemotherapy followed by radical surgery. Several open questions still remain unanswered and in particular no standard drug regiment is unanimously accepted. In this paper we describe how this treatment has evolved since its original introduction in the early eighties and describe possible drug regimens with their supporting evidence that can be adopted by physicians worldwide.
An update in neoadjuvant chemotherapy in cervical cancer / BENEDETTI PANICI, Pierluigi; Bellati, Filippo; Pastore, Maria; Natalina, Manci; Angela, Musella; Simona, Pauselli; Michela, Angelucci; Muzii, Ludovico; Roberto, Angioli. - In: GYNECOLOGIC ONCOLOGY. - ISSN 0090-8258. - 107:1(2007), pp. S20-S22. (Intervento presentato al convegno 5th International Conference on Cervical Cancer tenutosi a Venice, ITALY nel 2006) [10.1016/j.ygyno.2007.07.041].
An update in neoadjuvant chemotherapy in cervical cancer
BENEDETTI PANICI, PIERLUIGI;BELLATI, FILIPPO;PASTORE, MARIA;MUZII, LUDOVICO;
2007
Abstract
More than two decades have passed since neoadjuvant chemotherapy has been introduced in the clinical practice. After several pilot studies, randomized trials and meta-analysis have confirmed the validity of this therapeutic strategy and in particular of neoadjuvant chemotherapy followed by radical surgery. Several open questions still remain unanswered and in particular no standard drug regiment is unanimously accepted. In this paper we describe how this treatment has evolved since its original introduction in the early eighties and describe possible drug regimens with their supporting evidence that can be adopted by physicians worldwide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
