Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 x 10(4) in the most favorable case.
General Base-Guanidinium Cooperation in Bifunctional Artificial Phosphodiesterases / Salvio, Riccardo; R., Cacciapaglia; Mandolini, Luigi. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 76:13(2011), pp. 5438-5443. [10.1021/jo2004007]
General Base-Guanidinium Cooperation in Bifunctional Artificial Phosphodiesterases
SALVIO, RICCARDO;MANDOLINI, Luigi
2011
Abstract
Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 x 10(4) in the most favorable case.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
