Adipose tissue secretes of a range of biologically active proteins called adipokines. Dysregulation of adipokines is implicated in the etiology of insulin resistance and metabolic syndrome, but the relation between adiponectin, leptin and antiretroviral therapy has been poorly studied and subject to controversy. This study investigated the relation between plasma adipokine levels and different antiretroviral drug exposure in HIV positive subjects with similar metabolic and anthropometric parameters and without metabolic syndrome. Our data show that antiretroviral drugs impair the adipokine and osteoprotegerin profiles in HIV positive patients without metabolic syndrome and in the absence of impaired glycemic and lipidic parameters.

“Impaired adipokine profile in HIV positive patients without metabolic syndrome: the role of antiretroviral therapy.” / Ceccarelli, Giancarlo; Dettorre, G; Rizza, Mc; Massetti, Anna Paola; Mastroianni, Cm; Vullo, Vincenzo. - In: HAART AND CORRELATED PATHOLOGIES. - ISSN 1974-3246. - STAMPA. - 1:(2008), pp. 13-18.

“Impaired adipokine profile in HIV positive patients without metabolic syndrome: the role of antiretroviral therapy.”

CECCARELLI, GIANCARLO;DETTORRE G;MASSETTI, Anna Paola;MASTROIANNI CM;VULLO, Vincenzo
2008

Abstract

Adipose tissue secretes of a range of biologically active proteins called adipokines. Dysregulation of adipokines is implicated in the etiology of insulin resistance and metabolic syndrome, but the relation between adiponectin, leptin and antiretroviral therapy has been poorly studied and subject to controversy. This study investigated the relation between plasma adipokine levels and different antiretroviral drug exposure in HIV positive subjects with similar metabolic and anthropometric parameters and without metabolic syndrome. Our data show that antiretroviral drugs impair the adipokine and osteoprotegerin profiles in HIV positive patients without metabolic syndrome and in the absence of impaired glycemic and lipidic parameters.
2008
01 Pubblicazione su rivista::01a Articolo in rivista
“Impaired adipokine profile in HIV positive patients without metabolic syndrome: the role of antiretroviral therapy.” / Ceccarelli, Giancarlo; Dettorre, G; Rizza, Mc; Massetti, Anna Paola; Mastroianni, Cm; Vullo, Vincenzo. - In: HAART AND CORRELATED PATHOLOGIES. - ISSN 1974-3246. - STAMPA. - 1:(2008), pp. 13-18.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/348396
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact