Goal: To assess the clinical and endoscopic presentation of primary gastric lymphoma. Background: Remission rate and long-term survival in patients with gastric lymphoma mainly depend on disease stage at diagnosis. Series reporting clinical and endoscopic presentation of gastric lymphoma are generally small and heterogeneous. Study: Systematic review with pooled-data analysis assessing clinical and endoscopic presentation of primary gastric lymphoma. Results: Data regarding 2000 patients were collected. Overall, males were slightly more prevalent, alarm symptoms were absent in near half of the patients, lymphoma was diagnosed in a stage >I in one-third of the patients, and Helicobacter pylori infection was present in 88.8% of considered patients. At endoscopy, the ulcerative type was the most frequent presentation, although low-grade lymphoma was diagnosed on normal/hyperemic gastric mucosa in 9% of cases. Patients with high-grade lymphoma presented alarm symptoms (anemia and/or melena and/or hemorrhage, persistent vomiting, weight loss), an exophytic or ulcerative lesion, a stage III-IV, and a H. pylori negative status more frequently than low-grade lymphoma cases. Conclusions: Our pooled-data analysis showed that gastric lymphoma is still disappointingly diagnosed in an advanced stage in a large number of patients. This is probably due to presence of nonspecific symptoms at initial clinical presentation and/or a normal appearing mucosa at endoscopic observation in the early stages.

Primary Low-grade and High-grade Gastric MALT-lymphoma Presentation / A., Zullo; C., Hassan; A., Andriani; F., Cristofari; Cardinale, Vincenzo; Spinelli, GIAN PAOLO; Tomao, Silverio; S., Morini. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - 44:5(2010), pp. 340-344. [10.1097/mcg.0b013e3181b4b1ab]

Primary Low-grade and High-grade Gastric MALT-lymphoma Presentation

CARDINALE, VINCENZO;SPINELLI, GIAN PAOLO;TOMAO, SILVERIO;
2010

Abstract

Goal: To assess the clinical and endoscopic presentation of primary gastric lymphoma. Background: Remission rate and long-term survival in patients with gastric lymphoma mainly depend on disease stage at diagnosis. Series reporting clinical and endoscopic presentation of gastric lymphoma are generally small and heterogeneous. Study: Systematic review with pooled-data analysis assessing clinical and endoscopic presentation of primary gastric lymphoma. Results: Data regarding 2000 patients were collected. Overall, males were slightly more prevalent, alarm symptoms were absent in near half of the patients, lymphoma was diagnosed in a stage >I in one-third of the patients, and Helicobacter pylori infection was present in 88.8% of considered patients. At endoscopy, the ulcerative type was the most frequent presentation, although low-grade lymphoma was diagnosed on normal/hyperemic gastric mucosa in 9% of cases. Patients with high-grade lymphoma presented alarm symptoms (anemia and/or melena and/or hemorrhage, persistent vomiting, weight loss), an exophytic or ulcerative lesion, a stage III-IV, and a H. pylori negative status more frequently than low-grade lymphoma cases. Conclusions: Our pooled-data analysis showed that gastric lymphoma is still disappointingly diagnosed in an advanced stage in a large number of patients. This is probably due to presence of nonspecific symptoms at initial clinical presentation and/or a normal appearing mucosa at endoscopic observation in the early stages.
2010
clinical presentation; endoscopy; high-grade; low-grade; malt-lymphoma; symptoms
01 Pubblicazione su rivista::01a Articolo in rivista
Primary Low-grade and High-grade Gastric MALT-lymphoma Presentation / A., Zullo; C., Hassan; A., Andriani; F., Cristofari; Cardinale, Vincenzo; Spinelli, GIAN PAOLO; Tomao, Silverio; S., Morini. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - 44:5(2010), pp. 340-344. [10.1097/mcg.0b013e3181b4b1ab]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/339156
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