A simple thin-layer chromatographic method for the separation of D- and L-dansylamino acids using a new resolving agent is described. The enantiomeric resolution of racemates was accomplished on reversed-phase plates pre-treated with a poly-L-phenylalaninamide - copper(II) complex using water- acetonitrile mixtures as eluent under isocratic conditions. The polymeric ligand was easily prepared by reaction of the optically active amide with ethylene glycol diglycidyl ether at room temperature. The method is rapid and sensitive, and was successfully employed to resolve various dansylamino acids.

SEPARATION OF DANSYLAMINO ACID ENANTIOMERS BY THIN-LAYER CHROMATOGRAPHY / Massimo, Sinibaldi; Messina, Antonella; Girelli, Anna Maria. - In: ANALYST. - ISSN 0003-2654. - STAMPA. - 113:8(1988), pp. 1245-1247. [10.1039/an9881301245]

SEPARATION OF DANSYLAMINO ACID ENANTIOMERS BY THIN-LAYER CHROMATOGRAPHY

MESSINA, Antonella;GIRELLI, Anna Maria
1988

Abstract

A simple thin-layer chromatographic method for the separation of D- and L-dansylamino acids using a new resolving agent is described. The enantiomeric resolution of racemates was accomplished on reversed-phase plates pre-treated with a poly-L-phenylalaninamide - copper(II) complex using water- acetonitrile mixtures as eluent under isocratic conditions. The polymeric ligand was easily prepared by reaction of the optically active amide with ethylene glycol diglycidyl ether at room temperature. The method is rapid and sensitive, and was successfully employed to resolve various dansylamino acids.
1988
dansylamino acids; ligand-exchange chromatography; polymeric resolving agent; racemate resolution; thin-layer chromatography
01 Pubblicazione su rivista::01a Articolo in rivista
SEPARATION OF DANSYLAMINO ACID ENANTIOMERS BY THIN-LAYER CHROMATOGRAPHY / Massimo, Sinibaldi; Messina, Antonella; Girelli, Anna Maria. - In: ANALYST. - ISSN 0003-2654. - STAMPA. - 113:8(1988), pp. 1245-1247. [10.1039/an9881301245]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/33515
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