Three chiral stationary phases, obtained by grafting silica gel with (-)-trans-1,2-cyclohexanediamine, were studied for the resolution of -amino acids by ligand-exchange chromatography. The packings were prepared by bonding the chiral ligand to silica gel via different hydrocarbon spacers. Separation of the optical isomers was accomplished by eluents containing a constant concentration of copper(II) acetate (0.05mM). The elution sequence of amino acids was found to be dependent on the grafting reaction selected to prepare the chiral packings.

"High-performance ligand-exchange chromatography of amino acids on chiral stationary phases" / Carunchio, Vincenzo Tito; Messina, Antonella; Sinibaldi, M.; Fanali, S.. - In: HRC- JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY. - ISSN 0935-6304. - STAMPA. - 11:(1988), pp. 401-404. [10.1002/jhrc.1240110508]

"High-performance ligand-exchange chromatography of amino acids on chiral stationary phases"

CARUNCHIO, Vincenzo Tito;MESSINA, Antonella;
1988

Abstract

Three chiral stationary phases, obtained by grafting silica gel with (-)-trans-1,2-cyclohexanediamine, were studied for the resolution of -amino acids by ligand-exchange chromatography. The packings were prepared by bonding the chiral ligand to silica gel via different hydrocarbon spacers. Separation of the optical isomers was accomplished by eluents containing a constant concentration of copper(II) acetate (0.05mM). The elution sequence of amino acids was found to be dependent on the grafting reaction selected to prepare the chiral packings.
1988
Column liquid chromatography; Ligand-exchange chromatography; Chiral bonded phases; Racemate resolution; Amino acids
01 Pubblicazione su rivista::01a Articolo in rivista
"High-performance ligand-exchange chromatography of amino acids on chiral stationary phases" / Carunchio, Vincenzo Tito; Messina, Antonella; Sinibaldi, M.; Fanali, S.. - In: HRC- JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY. - ISSN 0935-6304. - STAMPA. - 11:(1988), pp. 401-404. [10.1002/jhrc.1240110508]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/33512
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