The influenza virus neuraminidase (NA) is an enzyme essential for viral infection and offers a potential target for antiviral drug development. We aimed our research at the synthesis of non-carbohydrate molecules able to inhibit NA as transition-state analogues. Aromatic sialic acid analogues (compound 5 and compound 10) were synthesised in good yields starting from commercially available benzoic acids using a suitable synthetic strategy. Copyright © 2001 Elsevier Science S.A.
Aromatic sialic acid analogues as potential inhibitors of influenza virus neuraminidase / Bianco, Armandodoriano; Brufani, Mario; Cristiana, Melchioni. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 56:4(2001), pp. 305-309. [10.1016/s0014-827x(01)01081-3]
Aromatic sialic acid analogues as potential inhibitors of influenza virus neuraminidase
BIANCO, Armandodoriano;BRUFANI, Mario;
2001
Abstract
The influenza virus neuraminidase (NA) is an enzyme essential for viral infection and offers a potential target for antiviral drug development. We aimed our research at the synthesis of non-carbohydrate molecules able to inhibit NA as transition-state analogues. Aromatic sialic acid analogues (compound 5 and compound 10) were synthesised in good yields starting from commercially available benzoic acids using a suitable synthetic strategy. Copyright © 2001 Elsevier Science S.A.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
