Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database / J., Avouac; U., Walker; A., Tyndall; A., Kahan; M., Matucci Cerinic; Y., Allanore; Eustar, ; I., Miniati; A., Muller; F., Iannone; O., Distler; R., Becvar; S., Sierakowsky; O., Kowal Bielecka; P., Coelho; J., Cabane; M., Cutolo; Y., Shoenfeld; G., Valentini; J., Rovensky; G., Riemekasten; P., Vlachoyiannopoulos; R., Caporali; S., Jiri; M., Inanc; I., Zimmermann Gorska; P., Carreira; S., Novak; L., Czirjak; F., Oliveira Ramos; M., Jendro; C., Chizzolini; E. J., Kucharz; J., Richter; F., Cozzi; B., Rozman; C. M., Mallia; A., Gabrielli; D., Farge; H. P., Kiener; D., Schoffel; P., Airo; F., Wollheim; D., Martinovic; F., Trotta; S., Jablonska; K., Reich; S., Bombardieri; P., Siakka; R., Pellerito; L. M., Bambara; J., Morovic Vergles; C., Denton; R., Hinrichs; F., Van Den Hoogen; N., Damjanov; I., Kotter; V., Ortiz; S., Heitmann; D., Krasowska; M., Seidel; P., Hasler; J. M., Van Laar; J. P., Kaltwasser; I., Foeldvari; A., Juan Mas; G., Bajocchi; M., Wislowska; J. A., Pereira Da Silva; S., Jacobsen; M., Worm; W., Graniger; A., Kuhn; A., Stankovic; R., Cossutta; M., Majdan; L., Damjanovska Rajcevska; M., Tikly; E. L., Nasonov; K., Steinbrink; A., Herrick; U., Muller Ladner; A., Dinc; R., Scorza; K., Sondergaard; F., Indiveri; H., Nielsen; Z., Szekanecz; R. M., Silver; M., Antivalle; I. B., Espinosa; P., Garcia De La Pena Lefebvre; O., Midtvedt; D., Launay; F., Valesini; P., Tuvik; R. M., Ionescu; N., Del Papa; S., Pinto; F., Wigley; C., Mihai; M., Sinziana Capranu; C., Sunderkotter; J. B., Jun; S., Alhasani; J. H., Distler; E., Ton; T., Soukup; J., Seibold; S., Zeni; P., Nash; L., Mouthon; F., De Keyser; M. T., Duruoz; F. P., Cantatore; G., Strauss; C. A., Von Mulhen; M. R., Pozzi; K., Eyerich; J., Szechinski; M., Keiserman; F. A., Houssiau; J. A., Roman Ivorra; B., Krummel Lorenz; M., Aringer; R., Westhovens; F., Bellisai; M., Mayer; F., Stoeckl; M., Uprus; A., Volpe; M., Buslau; S., Yavuz; B., Granel; A., Valderilio Feijo; F., Del Galdo; S., Popa; T., Zenone; X., Ricardo Machado; M., Pileckyte; S., Stebbings; A., Mathieu; A., Tulli; T., Tourinho; R., Souza; R., Acayaba De Toledo; L., Stamp; K., Solanki; D., Veale; Francisco J., Marques Neto; G. F., Bagnato; E., Loyo; S., Toloza; M., Li; Ahmed W., Abdel Atty Mohamed; V., Cobankara; J., Olas; Salsano, Felice; F., Oksel; C. M., Tanaseanu; R., Foti; C., Ancuta; M., Vonk; P., Caramashi; L., Beretta; A., Balbir; A., Chiala; K., Pasalic Simic; M., Ghio; B., Stamenkovic; S., Rednic; N., Host; R., Pellerito; E., Hachulla; D. E., Furst. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - STAMPA. - 37:7(2010), pp. 1488-1501. [10.3899/jrheum.091165]

Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database

SALSANO, Felice;
2010

Abstract

Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.
2010
joint contracture; joint involvement; synovitis; systemic sclerosis; tendon friction rub
01 Pubblicazione su rivista::01a Articolo in rivista
Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database / J., Avouac; U., Walker; A., Tyndall; A., Kahan; M., Matucci Cerinic; Y., Allanore; Eustar, ; I., Miniati; A., Muller; F., Iannone; O., Distler; R., Becvar; S., Sierakowsky; O., Kowal Bielecka; P., Coelho; J., Cabane; M., Cutolo; Y., Shoenfeld; G., Valentini; J., Rovensky; G., Riemekasten; P., Vlachoyiannopoulos; R., Caporali; S., Jiri; M., Inanc; I., Zimmermann Gorska; P., Carreira; S., Novak; L., Czirjak; F., Oliveira Ramos; M., Jendro; C., Chizzolini; E. J., Kucharz; J., Richter; F., Cozzi; B., Rozman; C. M., Mallia; A., Gabrielli; D., Farge; H. P., Kiener; D., Schoffel; P., Airo; F., Wollheim; D., Martinovic; F., Trotta; S., Jablonska; K., Reich; S., Bombardieri; P., Siakka; R., Pellerito; L. M., Bambara; J., Morovic Vergles; C., Denton; R., Hinrichs; F., Van Den Hoogen; N., Damjanov; I., Kotter; V., Ortiz; S., Heitmann; D., Krasowska; M., Seidel; P., Hasler; J. M., Van Laar; J. P., Kaltwasser; I., Foeldvari; A., Juan Mas; G., Bajocchi; M., Wislowska; J. A., Pereira Da Silva; S., Jacobsen; M., Worm; W., Graniger; A., Kuhn; A., Stankovic; R., Cossutta; M., Majdan; L., Damjanovska Rajcevska; M., Tikly; E. L., Nasonov; K., Steinbrink; A., Herrick; U., Muller Ladner; A., Dinc; R., Scorza; K., Sondergaard; F., Indiveri; H., Nielsen; Z., Szekanecz; R. M., Silver; M., Antivalle; I. B., Espinosa; P., Garcia De La Pena Lefebvre; O., Midtvedt; D., Launay; F., Valesini; P., Tuvik; R. M., Ionescu; N., Del Papa; S., Pinto; F., Wigley; C., Mihai; M., Sinziana Capranu; C., Sunderkotter; J. B., Jun; S., Alhasani; J. H., Distler; E., Ton; T., Soukup; J., Seibold; S., Zeni; P., Nash; L., Mouthon; F., De Keyser; M. T., Duruoz; F. P., Cantatore; G., Strauss; C. A., Von Mulhen; M. R., Pozzi; K., Eyerich; J., Szechinski; M., Keiserman; F. A., Houssiau; J. A., Roman Ivorra; B., Krummel Lorenz; M., Aringer; R., Westhovens; F., Bellisai; M., Mayer; F., Stoeckl; M., Uprus; A., Volpe; M., Buslau; S., Yavuz; B., Granel; A., Valderilio Feijo; F., Del Galdo; S., Popa; T., Zenone; X., Ricardo Machado; M., Pileckyte; S., Stebbings; A., Mathieu; A., Tulli; T., Tourinho; R., Souza; R., Acayaba De Toledo; L., Stamp; K., Solanki; D., Veale; Francisco J., Marques Neto; G. F., Bagnato; E., Loyo; S., Toloza; M., Li; Ahmed W., Abdel Atty Mohamed; V., Cobankara; J., Olas; Salsano, Felice; F., Oksel; C. M., Tanaseanu; R., Foti; C., Ancuta; M., Vonk; P., Caramashi; L., Beretta; A., Balbir; A., Chiala; K., Pasalic Simic; M., Ghio; B., Stamenkovic; S., Rednic; N., Host; R., Pellerito; E., Hachulla; D. E., Furst. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - STAMPA. - 37:7(2010), pp. 1488-1501. [10.3899/jrheum.091165]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/28418
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 37
  • Scopus 151
  • ???jsp.display-item.citation.isi??? 130
social impact