This retrospective study, including 118 patients with acute lymphoblastic leukemia (ALL) aged greater than 15 years, with a minimum follow-up of 6 years, was aimed at defining potentially "cured" adults with ALL. At present, 21 out of 92 patients who achieved complete remission (CR) are long survivors: 16 in first CR, off-therapy; 4 in 2nd CR (3 off-therapy); 1 in 3rd CR, on treatment. On the basis of available data, we tried to identify factors at diagnosis which might predict long-term survival: white blood cell (WBC) count on admission was the only significant prognostic factor for overall survival (p = 0.0002) and first CR duration (p = 0.0005). The survival hazard rate (risk of death from acute leukemia per day) reaches 0 between 8 and 9 years from diagnosis. From our data we can identify two groups of ALL long-term survivors: the first includes 16 patients in 1st continuous CR (CCR), 12 of whom in CCR for over 8 years may be considered "cured"; the second group comprises 5 patients, relapsing once or twice, alive in 2nd or 3rd CR.

ADULT ACUTE LYMPHOBLASTIC LEUKEMIA: DESCRIPTION AND ANALYSIS OF LONG TERM SURVIVORS. A RETROSPECTIVE STUDY / Giona, Fiorina; Mazzucconi, Maria Gabriella; ALOE SPIRITI, Maria Antonietta; D., De Fazio; De Luca, A. M.; G., Ferrazza; E., Martinelli; Mandelli, Franco. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 74:(1989), pp. 475-480.

ADULT ACUTE LYMPHOBLASTIC LEUKEMIA: DESCRIPTION AND ANALYSIS OF LONG TERM SURVIVORS. A RETROSPECTIVE STUDY

GIONA, Fiorina;MAZZUCCONI, Maria Gabriella;ALOE SPIRITI, Maria Antonietta;MANDELLI, Franco
1989

Abstract

This retrospective study, including 118 patients with acute lymphoblastic leukemia (ALL) aged greater than 15 years, with a minimum follow-up of 6 years, was aimed at defining potentially "cured" adults with ALL. At present, 21 out of 92 patients who achieved complete remission (CR) are long survivors: 16 in first CR, off-therapy; 4 in 2nd CR (3 off-therapy); 1 in 3rd CR, on treatment. On the basis of available data, we tried to identify factors at diagnosis which might predict long-term survival: white blood cell (WBC) count on admission was the only significant prognostic factor for overall survival (p = 0.0002) and first CR duration (p = 0.0005). The survival hazard rate (risk of death from acute leukemia per day) reaches 0 between 8 and 9 years from diagnosis. From our data we can identify two groups of ALL long-term survivors: the first includes 16 patients in 1st continuous CR (CCR), 12 of whom in CCR for over 8 years may be considered "cured"; the second group comprises 5 patients, relapsing once or twice, alive in 2nd or 3rd CR.
1989
01 Pubblicazione su rivista::01a Articolo in rivista
ADULT ACUTE LYMPHOBLASTIC LEUKEMIA: DESCRIPTION AND ANALYSIS OF LONG TERM SURVIVORS. A RETROSPECTIVE STUDY / Giona, Fiorina; Mazzucconi, Maria Gabriella; ALOE SPIRITI, Maria Antonietta; D., De Fazio; De Luca, A. M.; G., Ferrazza; E., Martinelli; Mandelli, Franco. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 74:(1989), pp. 475-480.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/414552
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