Patients with hepatitis C virus; (HCV) infection may have different patterns of antibody response to various structural and non-structural viral antigens. We have correlated the serological patterns to the clinical features of chronic infection and to viral replication in 68 HCV-Ab-positive patients with chronic liver disease at different stages (19 with cirrhosis-hepatocellular carcinoma, 38 with chronic active hepatitis and 11 with chronic persistent hepatitis). Serum samples from each patient were assayed for HCV-IgM by enzyme immunoassay and for HCV-RNA by the polymerase chain reaction using primer sets derived from the 5'-non-coding region. The prevalence of HCV-IgM was high (54 patients (79.4%)) and the study showed a good correlation between high values of anti-HCV-IgM and the presence of HCV-RNA in serum, since HCV-RNA was detected in 35 of tile 54 IgM-positive patients (64.8%) and notably in 19 of the 20 subjects with high levels of specific IgM. Conversely, all the 35 sera containing HCV-RNA were also reactive for HCV-IgM, while none of the HCV-IgM-negative sera was HCV-RNA reactive. Positivity rates for both HCV-RNA and IgM anti-HCV were higher in the more advanced stages of disease; thus, the clinical pattern of HCV chronic hepatitis seems to be strictly related to the serological pattern and the presence of HCV-RNA.

IgM anti-hepatitis C virus in patients with chronic non-A, non-B hepatitis and their relationship to viral replication / Mancini, Carlo; Rivanera, Daniela; Lilli, Daniela; G., Dicuonzo; S., Angeletti; G., Lorino; G. M., Desantis; I. G., Barbacini; G., Leonetti; P., Bianchi; L. V., Chircu; C., Galli. - In: CLINICAL AND DIAGNOSTIC VIROLOGY. - ISSN 0928-0197. - 4:4(1995), pp. 293-299. [10.1016/0928-0197(95)00021-6]

IgM anti-hepatitis C virus in patients with chronic non-A, non-B hepatitis and their relationship to viral replication

MANCINI, Carlo;RIVANERA, Daniela;LILLI, Daniela;
1995

Abstract

Patients with hepatitis C virus; (HCV) infection may have different patterns of antibody response to various structural and non-structural viral antigens. We have correlated the serological patterns to the clinical features of chronic infection and to viral replication in 68 HCV-Ab-positive patients with chronic liver disease at different stages (19 with cirrhosis-hepatocellular carcinoma, 38 with chronic active hepatitis and 11 with chronic persistent hepatitis). Serum samples from each patient were assayed for HCV-IgM by enzyme immunoassay and for HCV-RNA by the polymerase chain reaction using primer sets derived from the 5'-non-coding region. The prevalence of HCV-IgM was high (54 patients (79.4%)) and the study showed a good correlation between high values of anti-HCV-IgM and the presence of HCV-RNA in serum, since HCV-RNA was detected in 35 of tile 54 IgM-positive patients (64.8%) and notably in 19 of the 20 subjects with high levels of specific IgM. Conversely, all the 35 sera containing HCV-RNA were also reactive for HCV-IgM, while none of the HCV-IgM-negative sera was HCV-RNA reactive. Positivity rates for both HCV-RNA and IgM anti-HCV were higher in the more advanced stages of disease; thus, the clinical pattern of HCV chronic hepatitis seems to be strictly related to the serological pattern and the presence of HCV-RNA.
1995
chronic hepatitis; hepatitis c virus (hcv); immunoglobin m (igm); polymerase chain reaction (pcr)
01 Pubblicazione su rivista::01a Articolo in rivista
IgM anti-hepatitis C virus in patients with chronic non-A, non-B hepatitis and their relationship to viral replication / Mancini, Carlo; Rivanera, Daniela; Lilli, Daniela; G., Dicuonzo; S., Angeletti; G., Lorino; G. M., Desantis; I. G., Barbacini; G., Leonetti; P., Bianchi; L. V., Chircu; C., Galli. - In: CLINICAL AND DIAGNOSTIC VIROLOGY. - ISSN 0928-0197. - 4:4(1995), pp. 293-299. [10.1016/0928-0197(95)00021-6]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/256728
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 5
social impact