The reaction of alpha-trimethylsilanylmethyl)cyclohexylidene esters with NsONHCO(2)Et and CaO produces the N-(ethoxycarbonyl)spiroaziridines which, after ring-opening, gives the corresponding beta,beta-disubstituted (beta-amino ester derivatives. The stereochemical outcome of the reaction is influenced by substituents on the cyclohexyl group. (C) 2003 Elsevier Ltd. All rights reserved.
Synthesis of beta,beta-branched beta-amino ester derivatives through spiroaziridination of (alpha-trimethylsilanylmethyl)cyclohexylidene esters / T., Gasperi; Loreto, Maria Antonietta; Tardella, Paolo Antonio. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 44:46(2003), pp. 8467-8470. [10.1016/j.tetlet.2003.09.093]
Synthesis of beta,beta-branched beta-amino ester derivatives through spiroaziridination of (alpha-trimethylsilanylmethyl)cyclohexylidene esters
LORETO, Maria Antonietta;TARDELLA, Paolo Antonio
2003
Abstract
The reaction of alpha-trimethylsilanylmethyl)cyclohexylidene esters with NsONHCO(2)Et and CaO produces the N-(ethoxycarbonyl)spiroaziridines which, after ring-opening, gives the corresponding beta,beta-disubstituted (beta-amino ester derivatives. The stereochemical outcome of the reaction is influenced by substituents on the cyclohexyl group. (C) 2003 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
