postmortem and in vitro studies have shown that oxidative stress plays a role in the pathogenesis of many of the clinical features of Down's syndrome. The isoprostane 8,12-iso-iPF(2 alpha)-VI is a specific marker of lipid peroxidation. We found elevated levels of this isoprostane in urine samples of subjects with Down's syndrome compared with those of matched controls, which correlated with the duration of the disease. These results suggest that increased in vivo lipid peroxidation is a prominent component early in the course of Down's syndrome.
Down's syndrome is associated with increased 8,12-iso-iPF(2 alpha)-VI levels: Evidence for enhanced lipid peroxidation in vivo / D., Pratico; Iuliano, Luigi; G., Amerio; L. X., Tang; J., Rokach; J., Sabatino; Violi, Francesco. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - STAMPA. - 48:5(2000), pp. 795-798. [10.1002/1531-8249(200011)48:5<795::aid-ana15>3.0.co;2-#]
Down's syndrome is associated with increased 8,12-iso-iPF(2 alpha)-VI levels: Evidence for enhanced lipid peroxidation in vivo
IULIANO, Luigi;VIOLI, Francesco
2000
Abstract
postmortem and in vitro studies have shown that oxidative stress plays a role in the pathogenesis of many of the clinical features of Down's syndrome. The isoprostane 8,12-iso-iPF(2 alpha)-VI is a specific marker of lipid peroxidation. We found elevated levels of this isoprostane in urine samples of subjects with Down's syndrome compared with those of matched controls, which correlated with the duration of the disease. These results suggest that increased in vivo lipid peroxidation is a prominent component early in the course of Down's syndrome.File | Dimensione | Formato | |
---|---|---|---|
Praticò_Down's Syndrome_2000.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
587.37 kB
Formato
Adobe PDF
|
587.37 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.