Aims-To investigate whether lupus anticoagulant (LA) positivity, a marker of endothelial dysfunction, might be relevant to the pathogenesis of diabetic retinopathy (DR). Methods-32 IDDM patients were examined for LA, fibrinogen, prothrombin (PT), PTT, prothrombin degradation products (F1+2), and activated protein C (APC). Results-APC decreased and F1+2 increased significantly in LA positive but not in LA negative patients; 60% of LA positive and 18% of LA negative subjects had DR. PT, PTT, and fibrinogen levels were insignificant. Conclusion-These preliminary findings suggest that LA positivity could represent an additional risk factor for DR, acting as a link between the immunological and haemostatic systems.

Lupus anticoagulant positivity in insulin dependent diabetic patients: an additional risk factor in the pathogenesis of diabetic retinopathy? / C., Giusti; R., Schiaffini; D., Bosco; P., Ciampalini; A., Pantaleo; Vingolo, Enzo Maria; Gargiulo, Patrizia. - In: BRITISH JOURNAL OF OPHTHALMOLOGY. - ISSN 0007-1161. - STAMPA. - 84:5(2000), pp. 531-533. [10.1136/bjo.84.5.531]

Lupus anticoagulant positivity in insulin dependent diabetic patients: an additional risk factor in the pathogenesis of diabetic retinopathy?

VINGOLO, Enzo Maria;GARGIULO, Patrizia
2000

Abstract

Aims-To investigate whether lupus anticoagulant (LA) positivity, a marker of endothelial dysfunction, might be relevant to the pathogenesis of diabetic retinopathy (DR). Methods-32 IDDM patients were examined for LA, fibrinogen, prothrombin (PT), PTT, prothrombin degradation products (F1+2), and activated protein C (APC). Results-APC decreased and F1+2 increased significantly in LA positive but not in LA negative patients; 60% of LA positive and 18% of LA negative subjects had DR. PT, PTT, and fibrinogen levels were insignificant. Conclusion-These preliminary findings suggest that LA positivity could represent an additional risk factor for DR, acting as a link between the immunological and haemostatic systems.
2000
diabetic retinopathy; insulin dependent diabetic patients; lupus anticoagulant positivity in
01 Pubblicazione su rivista::01a Articolo in rivista
Lupus anticoagulant positivity in insulin dependent diabetic patients: an additional risk factor in the pathogenesis of diabetic retinopathy? / C., Giusti; R., Schiaffini; D., Bosco; P., Ciampalini; A., Pantaleo; Vingolo, Enzo Maria; Gargiulo, Patrizia. - In: BRITISH JOURNAL OF OPHTHALMOLOGY. - ISSN 0007-1161. - STAMPA. - 84:5(2000), pp. 531-533. [10.1136/bjo.84.5.531]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/254389
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