Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These liposomes are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MN154) show at specific charge ratios better transfection efficiency than that of some commercially available liposomes.
Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro / Claudio, Esposito; Masotti, Andrea; Nicoletta Del, Grosso; Daniela, Malizia; Bianco, Armandodoriano; Bonadies, Francesco; Napolitano, Raffaella; Ortaggi, Giancarlo; Giuseppe, Mossa. - In: COMPTES RENDUS CHIMIE. - ISSN 1631-0748. - STAMPA. - 6:5-6(2003), pp. 617-622. (Intervento presentato al convegno 3rd Italian-French Meeting on Organic Chemistry tenutosi a PISA, ITALY nel NOV 20-23, 2002) [10.1016/s1631-0748(03)00085-7].
Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro
MASOTTI, ANDREA;BIANCO, Armandodoriano;BONADIES, Francesco;NAPOLITANO, Raffaella;ORTAGGI, Giancarlo;
2003
Abstract
Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These liposomes are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MN154) show at specific charge ratios better transfection efficiency than that of some commercially available liposomes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
