Changes in brain lipid composition have been determined in 24 months-old Fischer rats with respect to 6 months-old ones. The cerebral levels of sphingomyelin and cholesterol were found to be significantly increased in aged rats, whereas the amount of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and phosphatidic acid appear to be unaffected by aging. Long-term feeding with acetyl-L-carnitine was able to reduce the age-dependent increase of both sphingomyelin and cholesterol cerebral levels with no effect on the other measured phospholipids. These findings shown that changes in membrane lipid metabolism and/or composition represent one of the alterations occurring in rat brain with aging, and that long-term feeding with acetyl-l-carnitine can be useful in normalizing these age-dependent disturbances.

Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by <SUP>31</SUP>P NMR spectroscopy / T., Aureli; DI COCCO, Maria Enrica; Capuani, Giorgio; R., Ricciolini; Manetti, Cesare; Miccheli, Alfredo; Conti, Filippo. - In: NEUROCHEMICAL RESEARCH. - ISSN 0364-3190. - STAMPA. - 25:3(2000), pp. 395-399. [10.1023/A:1007501306623]

Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31P NMR spectroscopy

DI COCCO, Maria Enrica;CAPUANI, Giorgio;MANETTI, Cesare;MICCHELI, Alfredo;CONTI, Filippo
2000

Abstract

Changes in brain lipid composition have been determined in 24 months-old Fischer rats with respect to 6 months-old ones. The cerebral levels of sphingomyelin and cholesterol were found to be significantly increased in aged rats, whereas the amount of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and phosphatidic acid appear to be unaffected by aging. Long-term feeding with acetyl-L-carnitine was able to reduce the age-dependent increase of both sphingomyelin and cholesterol cerebral levels with no effect on the other measured phospholipids. These findings shown that changes in membrane lipid metabolism and/or composition represent one of the alterations occurring in rat brain with aging, and that long-term feeding with acetyl-l-carnitine can be useful in normalizing these age-dependent disturbances.
2000
Acetyl-L-carnitine; aging brain; sphingomyelin; cholesterol; NMR spectroscopy
01 Pubblicazione su rivista::01a Articolo in rivista
Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by <SUP>31</SUP>P NMR spectroscopy / T., Aureli; DI COCCO, Maria Enrica; Capuani, Giorgio; R., Ricciolini; Manetti, Cesare; Miccheli, Alfredo; Conti, Filippo. - In: NEUROCHEMICAL RESEARCH. - ISSN 0364-3190. - STAMPA. - 25:3(2000), pp. 395-399. [10.1023/A:1007501306623]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/252739
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 24
social impact