An improved and efficient electrochemical N- acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhy- drides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.
Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2 / Feroci, Marta; Inesi, Achille; Palombi, L. M.; Sotgiu, G.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 67:(2002), pp. 1719-1721. [10.1021/jo016323a]
Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2
FEROCI, Marta;INESI, ACHILLE;
2002
Abstract
An improved and efficient electrochemical N- acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhy- drides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.| File | Dimensione | Formato | |
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