Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agrement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information From the intact system.
Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements / Capuani, Giorgio; Miccheli, Alfredo; Tomassini, Alberta; L., Falasca; T., Aureli; Conti, Filippo. - In: ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY. - ISSN 1073-1199. - 28:4(2000), pp. 293-305. [10.3109/10731190009119360]
Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements
CAPUANI, Giorgio;MICCHELI, Alfredo;TOMASSINI, Alberta;CONTI, Filippo
2000
Abstract
Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agrement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information From the intact system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
