The anelastic spectra of synthetic liposomes interesting for gene transfection have been measured in a wide temperature range; in particular, we have studied the cationic/neutral lipid mixture di-oleoyl trimethylammonium propane/di-oleoyl phosphatidylethanolamine at different molar ratios. This technique has been applied on thin films of biological samples deposited on a solid substrate like Si 100. We have evidenced the presence of two relaxation processes around and below 200 K, likely connected with a cooperative dynamics of the water plus membrane system. In particular, the process centered at 198 K results to be clearly a favorite by the presence of two different lipidic species.
Dynamics of liposomes gene vectors studied by anelastic spectroscopy / Castellano, C.; Pozzi, Daniela; Caracciolo, Giulio; Cantelli, Rosario. - In: APPLIED PHYSICS LETTERS. - ISSN 0003-6951. - 83:(2003), pp. 2701-2703. [10.1063/1.1611651]
Dynamics of liposomes gene vectors studied by anelastic spectroscopy
POZZI, DANIELA;CARACCIOLO, Giulio;CANTELLI, Rosario
2003
Abstract
The anelastic spectra of synthetic liposomes interesting for gene transfection have been measured in a wide temperature range; in particular, we have studied the cationic/neutral lipid mixture di-oleoyl trimethylammonium propane/di-oleoyl phosphatidylethanolamine at different molar ratios. This technique has been applied on thin films of biological samples deposited on a solid substrate like Si 100. We have evidenced the presence of two relaxation processes around and below 200 K, likely connected with a cooperative dynamics of the water plus membrane system. In particular, the process centered at 198 K results to be clearly a favorite by the presence of two different lipidic species.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
