Atopic dermatitis (AD) is a chronic dermatitis which belongs to the group of atopy-related diseases together with asthma and rhinitis. lgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an ltalian population. No significant association was found between AD and MCC genotypes. These data suggest that BstXl MCC polymorphism may not be involved in AD.
ABSENCE OF ASSOCIATION BETWEEN A VARIANT OF THE MAST CELL CHYMASE GENE AND ATOPIC DERMATITIS IN AN ITALIAN POPULATION / Pascale, Esterina; Tarani, Luigi; Meglio, P; Businco, L; Battiloro, E; CIMINO REALE, G; Verna, Roberto; D'Ambrosio, E.. - In: HUMAN HEREDITY. - ISSN 0001-5652. - STAMPA. - 51:(2001), pp. 177-179. [10.1159/000053339]
ABSENCE OF ASSOCIATION BETWEEN A VARIANT OF THE MAST CELL CHYMASE GENE AND ATOPIC DERMATITIS IN AN ITALIAN POPULATION
PASCALE, ESTERINA;TARANI, Luigi;VERNA, Roberto;
2001
Abstract
Atopic dermatitis (AD) is a chronic dermatitis which belongs to the group of atopy-related diseases together with asthma and rhinitis. lgE and mast cell chymase (MCC) play a key role in atopic or allergic inflammation of the skin. An association between AD and a genetic variant of the MCC has been reported in a Japanese population, but failure of confirmation has rendered this association questionable. We have tested for genetic association to an MCC variant in relation to AD in an ltalian population. No significant association was found between AD and MCC genotypes. These data suggest that BstXl MCC polymorphism may not be involved in AD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
