A new therapeutic approach to epatorenal syndrome

The hepatorenal syndrome is characterized, in essence, for progressive renal failure in a patient with advanced-stage liver disease and portal hypertension. The other features are: · Absence of an identifiable cause with only renal · Activation of endogenous vasoactive systems · Abnormalities of the arterial circulation with vasodilation system splacnico associated with vasoconstriction of the brachial artery, femoral and renal function. The renal artery vasoconstriction causes a speed reduction of glomerular filtration rate. Hemodynamic abnormalities and renal disease. In HRS there is an increase in cardiac output more than 10 liters / minute with reduction in systemic vascular resistance, often less than 500 dynes s / cm, reduction in blood pressure and increase in renal vascular resistance due to vasoconstriction of the renal artery with subsequent reduction in renal blood flow (RBF) and GFR