The effects of rat interferon (IFN) on the electrically-induced potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The treatment with rat IFN (120 U/ml) reduced the size of short-term potentiation (STP) and suppressed long-term potentiation (LTP). These IFN-induced effects were dose-dependent in the range of 50-500 U/ml. In addition, IFN slightly attenuated the potentiation when applied during the maintenance of LTP. Basal synaptic transmission was affected by IFN at concentrations greater-than-or-equal-to 250 U/ml. Following an acute exposure to IFN (500-2000 U/ml), cultured embryonic neurones from rat hippocampus often exhibited an attenuation of N-methyl-D-aspartate-induced currents and a variation (increase or decrease) of voltage-activated Ca2+ current amplitude. A possible role of IFN as neuromodulator in mammalian brain during immune responses is discussed.
INTERFERON INHIBITS SYNAPTIC POTENTIATION IN RAT HIPPOCAMPUS / G., Darcangelo; Grassi, Francesca; Ragozzino, Davide Antonio; Santoni, Angela; Virginia, Tancredi; Eusebi, Fabrizio. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 564:2(1991), pp. 245-248. [10.1016/0006-8993(91)91459-e]
INTERFERON INHIBITS SYNAPTIC POTENTIATION IN RAT HIPPOCAMPUS
GRASSI, Francesca;RAGOZZINO, Davide Antonio;SANTONI, Angela;EUSEBI, Fabrizio
1991
Abstract
The effects of rat interferon (IFN) on the electrically-induced potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The treatment with rat IFN (120 U/ml) reduced the size of short-term potentiation (STP) and suppressed long-term potentiation (LTP). These IFN-induced effects were dose-dependent in the range of 50-500 U/ml. In addition, IFN slightly attenuated the potentiation when applied during the maintenance of LTP. Basal synaptic transmission was affected by IFN at concentrations greater-than-or-equal-to 250 U/ml. Following an acute exposure to IFN (500-2000 U/ml), cultured embryonic neurones from rat hippocampus often exhibited an attenuation of N-methyl-D-aspartate-induced currents and a variation (increase or decrease) of voltage-activated Ca2+ current amplitude. A possible role of IFN as neuromodulator in mammalian brain during immune responses is discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
