The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.
The 5' sequence of human factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes / Citarella, Franca; Misiti, Silvia; Felici, A; Aiuti, A; LA PORTA, C; Fantoni, Antonio. - In: BIOCHIMICA ET BIOPHYSICA ACTA. - ISSN 0006-3002. - ELETTRONICO. - 1172(1-2):(1993), pp. 197-199. [10.1016/0167-4781(93)90294-N]
The 5' sequence of human factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes
CITARELLA, Franca;MISITI, Silvia;FANTONI, Antonio
1993
Abstract
The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
