Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF. Incubating aspirin-treated platelets with 50-100 microM vitamin E or vitamin E acetate inhibited platelet aggregation by high concentrations of collagen and PAF and by the combination of epinephrine and PAF; platelet thromboxane A2 formation was less than 10% in samples incubated with 100 microM aspirin. Apyrase, added to aspirin-treated platelet, did not influence platelet aggregation induced by epinephrine and PAF. The present study suggests that concentrations of vitamin E as low as 50-100 microM inhibit cyclooxygenase-independent platelet aggregation when combined with an inhibitor of the arachidonate pathway.

Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration / Violi, F; Pratico, D; Ghiselli, A; Alessandri, Cesare; Iuliano, Luigi; Cordova, C; Balsano, F.. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - STAMPA. - 82:(1990), pp. 247-252. [10.1016/0021-9150(90)90046-L]

Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration.

ALESSANDRI, Cesare;IULIANO, Luigi;
1990

Abstract

Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF. Incubating aspirin-treated platelets with 50-100 microM vitamin E or vitamin E acetate inhibited platelet aggregation by high concentrations of collagen and PAF and by the combination of epinephrine and PAF; platelet thromboxane A2 formation was less than 10% in samples incubated with 100 microM aspirin. Apyrase, added to aspirin-treated platelet, did not influence platelet aggregation induced by epinephrine and PAF. The present study suggests that concentrations of vitamin E as low as 50-100 microM inhibit cyclooxygenase-independent platelet aggregation when combined with an inhibitor of the arachidonate pathway.
1990
platelet aggregation; vitamin E; alpha-tocopherol; thrombosis; atherosclerosis
01 Pubblicazione su rivista::01a Articolo in rivista
Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration / Violi, F; Pratico, D; Ghiselli, A; Alessandri, Cesare; Iuliano, Luigi; Cordova, C; Balsano, F.. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - STAMPA. - 82:(1990), pp. 247-252. [10.1016/0021-9150(90)90046-L]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242480
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