The behavioral response of planaria to the exposure to selective opioid agonists was studied. The m agonist [d-ala2 , N-methyl-Phe4 ,Gly5 -ol]enkephalin (DAMGO) and the d agonist [D-Pen2 , D-Pen5 ]enkephalin (DPDPE) failed to alter motor activity at all doses tested. Low doses of the selective k agonist (9)-trans-U-50-trans-3,4-dichloro-N-methyl-N[2-(1-pyrrodinyl)- cyclohexyl]benzene acetamide methasulphonate (U50, 488) and bremazocine–HCl increased motor activity leading to C-like position (CLP) and screw-like hyperkinesia (SLH). These changes were identical to those seen previously with the exposure to D2 or D1 dopamine receptor agonists, respectively. Higher doses of k agonists produced the enhancement of CLP and SLH together with robust snake-like movements (SLM). This latter response, that was typical of stimulation of k opioid receptors, was blocked by co-exposure to naloxone or the selective k antagonist Nor-binaltorphimine (Nor-BNI). Finally, co-exposure to sulpiride or SH-23390 respectively blocked the CLP or SLH response produced by U50,488 or bremazocine. Our data indicate the presence of k opioid receptors in planaria and suggest the functional interaction between the opioid and dopamine system in this simple animal model.

Opioid-dopamine interaction in planaria: a behavioral study / Passarelli, Francesca; Merante, A; Pontieri, FRANCESCO ERNESTO; Margotta, Vito; Venturini, Giorgio; Palladini, Guido. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART C, PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY. - ISSN 1367-8280. - ELETTRONICO. - 124C:(1999), pp. 51-55. [10.1016/S0742-8413(99)00048-1]

Opioid-dopamine interaction in planaria: a behavioral study

PASSARELLI, Francesca;PONTIERI, FRANCESCO ERNESTO;MARGOTTA, Vito;VENTURINI, Giorgio;PALLADINI, Guido
1999

Abstract

The behavioral response of planaria to the exposure to selective opioid agonists was studied. The m agonist [d-ala2 , N-methyl-Phe4 ,Gly5 -ol]enkephalin (DAMGO) and the d agonist [D-Pen2 , D-Pen5 ]enkephalin (DPDPE) failed to alter motor activity at all doses tested. Low doses of the selective k agonist (9)-trans-U-50-trans-3,4-dichloro-N-methyl-N[2-(1-pyrrodinyl)- cyclohexyl]benzene acetamide methasulphonate (U50, 488) and bremazocine–HCl increased motor activity leading to C-like position (CLP) and screw-like hyperkinesia (SLH). These changes were identical to those seen previously with the exposure to D2 or D1 dopamine receptor agonists, respectively. Higher doses of k agonists produced the enhancement of CLP and SLH together with robust snake-like movements (SLM). This latter response, that was typical of stimulation of k opioid receptors, was blocked by co-exposure to naloxone or the selective k antagonist Nor-binaltorphimine (Nor-BNI). Finally, co-exposure to sulpiride or SH-23390 respectively blocked the CLP or SLH response produced by U50,488 or bremazocine. Our data indicate the presence of k opioid receptors in planaria and suggest the functional interaction between the opioid and dopamine system in this simple animal model.
1999
Planaria; Opioids; Dopamine; Receptors; Behavior; Bremazocine; U50,488; Nor-BNI
01 Pubblicazione su rivista::01a Articolo in rivista
Opioid-dopamine interaction in planaria: a behavioral study / Passarelli, Francesca; Merante, A; Pontieri, FRANCESCO ERNESTO; Margotta, Vito; Venturini, Giorgio; Palladini, Guido. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART C, PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY. - ISSN 1367-8280. - ELETTRONICO. - 124C:(1999), pp. 51-55. [10.1016/S0742-8413(99)00048-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242030
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