Background: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53. Methods: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses. Results: A positive statistically significant correlation was found between p27 and p21 expression (p< 0.0001), but there was a negative correlation between COX-2 expression and both p27 ( p = 0.001) and p21 ( p, 0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2. Conclusions: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.

Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma / Baldi, A.; Santini, D.; Vasaturo, F.; Santini, M.; Vicidomini, G.; Pia Di Marino, M.; Esposito, V.; Groeger, A. M.; Liuzzi, G.; Vincenzi, B.; Tonini, G.; Piccoli, Mario; Baldi, F.; Scarpa, Susanna. - In: THORAX. - ISSN 0040-6376. - 59:5(2004), pp. 428-433. [10.1136/thx.2003.008912]

Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma

D. Santini;PICCOLI, Mario;SCARPA, Susanna
2004

Abstract

Background: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53. Methods: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses. Results: A positive statistically significant correlation was found between p27 and p21 expression (p< 0.0001), but there was a negative correlation between COX-2 expression and both p27 ( p = 0.001) and p21 ( p, 0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2. Conclusions: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.
2004
01 Pubblicazione su rivista::01a Articolo in rivista
Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma / Baldi, A.; Santini, D.; Vasaturo, F.; Santini, M.; Vicidomini, G.; Pia Di Marino, M.; Esposito, V.; Groeger, A. M.; Liuzzi, G.; Vincenzi, B.; Tonini, G.; Piccoli, Mario; Baldi, F.; Scarpa, Susanna. - In: THORAX. - ISSN 0040-6376. - 59:5(2004), pp. 428-433. [10.1136/thx.2003.008912]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/241229
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