NK cells promote adaptive immune responses through their production of type I and type 2 cytokines or chemokines. Secretion of these factors by activated NK cells influences the differentiation of B and T lymphocytes. Increasing evidence indicates that NK cells are also directly involved in dendritic cell (DC) maturation. By contrast, a potential role for direct cell-cell interactions between NK and T lymphocytes, in particular CD4(+) T cells, has not been explored. We provide evidence that activated human NK cells are able of promoting TcR-dependent proliferation of resting autologous peripheral blood CD4(+) T cells by a process that involves costimulatory molecules of the immunoglobulin (Ig) and tumor necrosis factor (TNF) superfamilies. These findings suggest a novel link between natural and adaptative immune responses. (C) 2004 Elsevier Ltd. All rights reserved.
NK cell regulation of T cell-mediated responses / Zingoni, Alessandra; Sornasse, Thierry; G., Cocksc Benjamin; Yuetsu, Tanaka; Santoni, Angela; Lewis L., Lanier. - In: MOLECULAR IMMUNOLOGY. - ISSN 0161-5890. - STAMPA. - 42:4 SPEC. ISS.(2005), pp. 451-454. (Intervento presentato al convegno 20th International Natural Killer Cell Workshop tenutosi a Noordwijkerhout, NETHERLANDS nel APR 24-28, 2004) [10.1016/j.molimm.2004.07.025].
NK cell regulation of T cell-mediated responses
ZINGONI, Alessandra;SANTONI, Angela;
2005
Abstract
NK cells promote adaptive immune responses through their production of type I and type 2 cytokines or chemokines. Secretion of these factors by activated NK cells influences the differentiation of B and T lymphocytes. Increasing evidence indicates that NK cells are also directly involved in dendritic cell (DC) maturation. By contrast, a potential role for direct cell-cell interactions between NK and T lymphocytes, in particular CD4(+) T cells, has not been explored. We provide evidence that activated human NK cells are able of promoting TcR-dependent proliferation of resting autologous peripheral blood CD4(+) T cells by a process that involves costimulatory molecules of the immunoglobulin (Ig) and tumor necrosis factor (TNF) superfamilies. These findings suggest a novel link between natural and adaptative immune responses. (C) 2004 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
