Hepatocyte growth factor (HGF) is a pleiotropic factor which activates cell proliferation, differentiation and migration of various cell types. Its action is mediated by a receptor, Met, endowed with tyrosine kinase activity, which activates a complex signalling cascade and mediates the diverse cell responses. Although HGF action has been first demonstrated on epithelial cells, HGF and Met receptor expression have also been described in the developing and adult mammalian brain. In the developing brain HGF and Met expression areas are coincident with the migratory paths of precursor cells. These data will be reviewed together with cell culture data, which directly support a role for HGF in precursor cell migration and neuron differentiation.

Hepatocyte growth factor and cell migration in neurogenesis / Soldati, Chiara; Biagioni, Stefano; Poiana, Giancarlo; Tocco, Gabriella. - In: TRENDS IN DEVELOPMENTAL BIOLOGY. - ISSN 0972-8422. - STAMPA. - 1:(2005), pp. 107-116.

Hepatocyte growth factor and cell migration in neurogenesis

SOLDATI, chiara;BIAGIONI, Stefano;POIANA, Giancarlo;TOCCO, Gabriella
2005

Abstract

Hepatocyte growth factor (HGF) is a pleiotropic factor which activates cell proliferation, differentiation and migration of various cell types. Its action is mediated by a receptor, Met, endowed with tyrosine kinase activity, which activates a complex signalling cascade and mediates the diverse cell responses. Although HGF action has been first demonstrated on epithelial cells, HGF and Met receptor expression have also been described in the developing and adult mammalian brain. In the developing brain HGF and Met expression areas are coincident with the migratory paths of precursor cells. These data will be reviewed together with cell culture data, which directly support a role for HGF in precursor cell migration and neuron differentiation.
2005
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatocyte growth factor and cell migration in neurogenesis / Soldati, Chiara; Biagioni, Stefano; Poiana, Giancarlo; Tocco, Gabriella. - In: TRENDS IN DEVELOPMENTAL BIOLOGY. - ISSN 0972-8422. - STAMPA. - 1:(2005), pp. 107-116.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/236155
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact